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Sarcoma
Volume 2012 (2012), Article ID 820254, 12 pages
http://dx.doi.org/10.1155/2012/820254
Research Article

Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

1Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
2GeneGo, Inc., 500 Renaissance Drive, No. 106, St. Joseph, MI 49085, USA
3Department of Pathology and Laboratory Medicine, Children’s Memorial Hospital 2300 Children’s Plaza, Chicago, IL 60614, USA
4Center for Bioinformatics and Computation Biology, University of Iowa, 5316 Seamans Center, Iowa City, IA 52242, USA
5Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
6Vavilov Institute for General Genetics, Russian Academy of Sciences, 3 Gubkina Street, Moscow 117093, Russia
7Department of Urology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
8Department of Hematology/Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
9Department of Surgical Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
10Lung Cancer and Thoracic Oncology Program, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
11Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA

Received 12 May 2011; Revised 21 October 2011; Accepted 3 November 2011

Academic Editor: Alessandro Gronchi

Copyright © 2012 Sergey Malchenko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.