Table 2: “Biased multifunctional signature” of dedifferentiated chondrosarcoma lung metastases.

Upregulated in Met.-cell lines
Gene nameGene symbol

Plasminogen activator, TissuePLAT*
Plasminogen activator, UrokinasePLAU*
Interleukin 8IL8*
Chemokine (C-C motif) ligand 2CCL2
Integrin, beta 1ITGB1
Actin, betaACTB
VinculinVCL
Drebrin 1DBN1*
MoesinMSN*
Tissue factor pathway inhibitor 2TFPI2*
Caveolin 1CAV1
Caveolin 2CAV2*
Tenascin-CTNC*

Downregulated in Met.-cell lines

Transforming growth factor, beta-induced, 68 kDATGFBI
Serpin peptidase inhibitor, clade E, member 2SERPINE2

*Genes uniquely expressed in the metastases.