Review Article
The Molecular Biology of Soft-Tissue Sarcomas and Current Trends in Therapy
Table 2
HIV and Kaposi Sarcoma. HHV-8 genes activated by HIV-Tat.
| | HHV-8 genes | Effects | Other properties |
| | vGPCR (ORF 74) | Constitutively activates GPCR
Promotes synthesis of VEGF | Oncogenic
Angiogenic | | vBcI2 (ORF 16) | Antiapoptotic activity
Inhibits bax | Oncogenic | | vIRF-1 (ORF K9) | Interferon regulatory factor homolog
Activates the c-myc oncogene | Antagonizes IFN-mediated antiviral immunity |
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