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Figure 4: Clinical application of a cell-free polycaprolactone-calcium phosphate scaffold for bone regeneration in a calvarial defect. Scaffold designed using CT imaging data and fabricated by fused deposition modeling (a). Calvarial defect (b). Defect after implantation of the scaffold (c). CT images showing bony consolidation of the defect after 6 months (d). Reproduced with permission from Georg Thieme Verlag (2012) [3].