Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells
Figure 3
Appearance over time of experimental metastases in indicated organs after intravenous injection of lacZ-transduced Dunn and LM8 cells in C3H mice. ((a)–(c)) Images show X-gal-stained metastases in blue in representative whole mounts and ((a), (b)) corresponding close-ups of lungs (a), livers (b), and kidneys (c) collected from mice that were sacrificed at indicated time points after tumor cell injection. (d) Schematic summary of the first appearance of micro- and macrometastases (>0.1 mm) over time in indicated organs.
