About this Journal Submit a Manuscript Table of Contents
Sarcoma
Volume 2013 (2013), Article ID 404962, 13 pages
http://dx.doi.org/10.1155/2013/404962
Research Article

Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells

Laboratory for Orthopedic Research, Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland

Received 24 July 2013; Revised 13 October 2013; Accepted 13 October 2013

Academic Editor: Akira Kawai

Copyright © 2013 Matthias J. E. Arlt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. T. H. Ek, C. R. Dass, and P. F. M. Choong, “Commonly used mouse models of osteosarcoma,” Critical Reviews in Oncology/Hematology, vol. 60, no. 1, pp. 1–8, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. T. B. Dunn and H. B. Andervont, “Histology of some neoplasms and non-neoplastic lesions found in wild mice maintained under laboratory conditions,” Journal of the National Cancer Institute, vol. 31, pp. 873–901, 1963. View at Scopus
  3. T. Asai, T. Ueda, K. Itoh, et al., “Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung,” International Journal of Cancer, vol. 76, no. 3, pp. 418–422, 1998.
  4. G. Poste and I. J. Fidler, “The pathogenesis of cancer metastasis,” Nature, vol. 283, no. 5743, pp. 139–146, 1980. View at Scopus
  5. M. J. E. Arlt, I. J. Banke, D. K. Walters et al., “LacZ transgene expression in the subcutaneous Dunn/LM8 osteosarcoma mouse model allows for the identification of micrometastasis,” Journal of Orthopaedic Research, vol. 29, no. 6, pp. 938–946, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. C. Chiang and J. Massague, “Molecular basis of metastasis,” The New England Journal of Medicine, vol. 359, no. 26, pp. 2814–2823, 2008.
  7. G. P. Gupta and J. Massagué, “Cancer metastasis: building a framework,” Cell, vol. 127, no. 4, pp. 679–695, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. D. X. Nguyen and J. Massagué, “Genetic determinants of cancer metastasis,” Nature Reviews Genetics, vol. 8, no. 5, pp. 341–352, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. D. X. Nguyen, P. D. Bos, and J. Massagué, “Metastasis: from dissemination to organ-specific colonization,” Nature Reviews Cancer, vol. 9, no. 4, pp. 274–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Muff, R. M. Ram Kumar, S. M. Botter, W. Born, and B. Fuchs, “Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems,” Sarcoma, vol. 2012, Article ID 937506, 13 pages, 2012. View at Publisher · View at Google Scholar
  11. D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources,” Nature Protocols, vol. 4, no. 1, pp. 44–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. Minn, Y. Kang, I. Serganova et al., “Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors,” Journal of Clinical Investigation, vol. 115, no. 1, pp. 44–55, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Páez, M. J. Labonte, P. Bohanes et al., “Cancer dormancy: a model of early dissemination and late cancer recurrence,” Clinical Cancer Research, vol. 18, no. 3, pp. 645–653, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Bragado, M. S. Sosa, P. Keely, J. Condeelis, and J. A. Aguirre-Ghiso, “Microenvironments dictating tumor cell dormancy,” Recent Results in Cancer Research, vol. 195, pp. 25–39, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Almog, L. Ma, R. Raychowdhury et al., “Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype,” Cancer Research, vol. 69, no. 3, pp. 836–844, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Hüsemann, J. B. Geigl, F. Schubert et al., “Systemic spread is an early step in breast cancer,” Cancer Cell, vol. 13, no. 1, pp. 58–68, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Schmidt-Kittler, T. Ragg, A. Daskalakis et al., “From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 13, pp. 7737–7742, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Kashima, K. Nakamura, J. Kawaguchi et al., “Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo,” International Journal of Cancer, vol. 104, no. 2, pp. 147–154, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Egeblad and Z. Werb, “New functions for the matrix metalloproteinases in cancer progression,” Nature Reviews Cancer, vol. 2, no. 3, pp. 161–174, 2002. View at Scopus
  20. L. A. Liotta and E. C. Kohn, “The microenvironment of the tumour—host interface,” Nature, vol. 411, no. 6835, pp. 375–379, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Podsypanina, Y.-C. N. Du, M. Jechlinger, L. J. Beverly, D. Hambardzumyan, and H. Varmus, “Seeding and propagation of untransformed mouse mammary cells in the lung,” Science, vol. 321, no. 5897, pp. 1841–1844, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. F. V. Jacinto, E. Ballestar, S. Ropero, and M. Esteller, “Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells,” Cancer Research, vol. 67, no. 24, pp. 11481–11486, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Taylor, J. Hickson, T. Lotan, D. S. Yamada, and C. Rinker-Schaeffer, “Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment,” Cancer and Metastasis Reviews, vol. 27, no. 1, pp. 67–73, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Heese, T. Yamada, H. Akatsu et al., “Characterizing the new transcription regulator protein p60TRP,” Journal of Cellular Biochemistry, vol. 91, no. 5, pp. 1030–1042, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Pancione, L. Sabatino, A. Fucci et al., “Epigenetic silencing of peroxisome proliferator- activated receptor γ is a biomarker for colorectal cancer progression and adverse patients' outcome,” PLoS ONE, vol. 5, no. 12, Article ID e14229, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Bierie and H. L. Moses, “Tumour microenvironment—TGFΒ: the molecular Jekyll and Hyde of cancer,” Nature Reviews Cancer, vol. 6, no. 7, pp. 506–520, 2006. View at Publisher · View at Google Scholar · View at Scopus