Table 2: Genes involved in cancer pathways (KEGG pathway; DAVID) and whose expression is significantly down- or upregulated in LM8 compared to Dunn cells.

SymbolFold changeP value

Genes downregulated in LM8 cells
 Kit ligandKitl−24.57
 Peroxisome proliferator activated receptor gammaPparg−15.70
 Vascular endothelial growth factor CVegfc−8.20
 Prostaglandin-endoperoxide synthase 2Ptgs2−7.46
 Similar to platelet-derived growth factor B chain; platelet-derived growth factor, B polypeptidePdgfb−5.95
 Insulin-like growth factor 1Igf1−4.70
 Aryl hydrocarbon receptor nuclear translocator 2Arnt2−3.80
 Endothelial PAS domain protein 1; similar to endothelial PAS domain protein 1Epas1−3.62
 Fibronectin 1Fn1−2.95
 Integrin alpha 3Itga3−2.79
 Integrin alpha 6Itga6−2.78
 Laminin B1 subunit 1Lamb1-1−2.64
 Transforming growth factor, beta 2Tgfb2−2.43
 RAS-related C3 botulinum substrate 3Rac3−2.37
 Bone morphogenetic protein 4Bmp4−2.26
 Signal transducer and activator of transcription 3; similar to Stat3BStat3−2.23
 Transforming growth factor, beta receptor ITgfbr1−2.15
 Fibroblast growth factor receptor 2Fgfr2−2.14
 Interleukin 6Il6−2.01
Genes upregulated in LM8 cells
 Matrix metallopeptidase 2Mmp26.91
 Death-associated protein kinase 2Dapk24.70
 Transcription factor 7, T-cell specificTcf73.82
 Wingless-related MMTV integration site 1Wnt13.24
 Baculoviral IAP repeat-containing 3Birc33.18
 Patched homolog 2Ptch23.02
 Frizzled homolog 7 (Drosophila)Fzd72.94
 Wingless-related MMTV integration site 10aWnt10a2.64
 Fibroblast growth factor 15Fgf152.63
 GLI-Kruppel family member GLI2Gli22.59
 Similar to wingless-related MMTV integration site 8b; wingless-related MMTV integration site 8bWnt8b2.39
 Predicted gene 10124; predicted gene 6340; CDC28 protein kinase 1bCks1b2.29

Genes with >2 times decrease or increase in expression and a P value < 0.05 were selected and applied to the DAVID program.