Table 3: Regulation of potential dormancy genes in LM8 compared to Dunn cells.

SymbolFold changeP value

Genes downregulated in LM8
 Basic helix-loop-helix domain containing, class B9Bhlhb9−60.98
 Fibronectin 1Fn1−2.95
 Transforming growth factor, beta 2Tgfb2−2.43
 Rous sarcoma oncogeneSrc−2.36
 Tropomyosin 1, alphaTpm1−2.28
 Transforming growth factor, beta receptor ITgfbr1−2.15
Genes upregulated in LM8
 Connective tissue growth factor Ctgf2.72
Genes not differentially regulated in LM8
 Secreted phosphoprotein 1Spp1−1.78
 A kinase (PRKA) anchor protein (gravin) 12; SSeCKSAkap12−1.67
 plasminogen activator, urokinase receptor; uPARPlaur−1.59
 Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); INK4b; p15Cdkn2b−1.47
 Discoidin domain receptor family, member 2Ddr2−1.46
 AngiomotinAmot−1.16
 Thrombospondin 1Thbs1−1.13
 Nuclear receptor subfamily 2, group F, member 2Nr2f2−1.10
 Basic helix-loop-helix family, member e41; Sharp1; Bhlhb3; Bhlhb2lBhlhe41−1.09
 Smad family member 7Smad7−1.07
 NME/NM23 nucleoside diphosphate kinase 1Nme1−1.03
 Insulin-like growth factor binding protein 5IGFBP5−1.03
 Integrin alpha 5 (fibronectin receptor alpha)Itga5−1.02
 Mitogen-activated protein kinase kinase 7; MKK7Map2k7−1.01
 Rho, GDP dissociation inhibitor (GDI) beta; RhoGD12Arhgdib−1.01
 Mitogen-activated protein kinase 14; p38Mapk14−1.01
 Eph receptor A5EphA5−1.01
 Integrin beta 1 (fibronectin receptor beta)Itgb11.01
 Transformation related protein 53; p53Trp531.02
 Endothelial cell-specific molecule 1Esm11.03
 Mitogen-activated protein kinase kinase 4; MKK4Map2k41.04
 Tissue inhibitor of metalloproteinases 3Timp31.04
 Eph receptor B2; ErkEphb21.05
 CD82 antigen; Kai1Cd82 1.06
 Mitogen-activated protein kinase kinase 6; MKK6Map2k61.07
 5′ Nucleotidase, ecto; CD73Nt5e1.08
 Epidermal growth factor receptorEgfr1.11
 Phosphatidylinositol 3-kinase, catalytic, beta polypeptidePI3K (Pik3cb)1.12
 Twist basic helix-loop-helix transcription factor 2Twist21.13
 Mediator complex subunit 23; CRSP3Med23 1.15
 Lysophosphatidic acid receptor 1; Edg2Lpar11.19
 Breast cancer metastasis-suppressor 1-likeBrms1l1.27
 GATA binding protein 3Gata31.34
 Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptideP4ha11.75

Genes with >2 times decrease or increase in expression and a P value < 0.05 were considered as significantly regulated. For Igf1r, Kiss1, and Hist1h2bk no data were available on the microarray.