Table 2: High risk protocol roadmap.

Weeks 0 1 2 34 5 67 8 910 1112
VACV VVACV VVACV VVACV VVAC **

Weeks 1314 15 1617 18 1920 21 2223 2425
VC VC VV VVACVV**VAC

Weeks 2627 28 2930 31 3233 34 3536 3740
VVVACVAC VVVAC VVVAC **

Vincristine (V): 1.5 mg/m2 IV push.
Actinomycin (A): 1.35 mg/m2 IV push.
Cyclophosphamide (C): 1.5 mg/m2 at weeks 0 and 3 to be increased to 1.8 gm/m2 if tolerated, given IV infusion over 2 hours with MESNA and fluids.
**Time of re-evaluation (at weeks 12, 24, and 40 end of therapy).