|Table 2: High risk protocol roadmap.|
|Vincristine (V): 1.5 mg/m2 IV push. |
Actinomycin (A): 1.35 mg/m2 IV push.
Cyclophosphamide (C): 1.5 mg/m2 at weeks 0 and 3 to be increased to 1.8 gm/m2 if tolerated, given IV infusion over 2 hours with MESNA and fluids.
**Time of re-evaluation (at weeks 12, 24, and 40 end of therapy).