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Sarcoma
Volume 2013 (2013), Article ID 480713, 11 pages
http://dx.doi.org/10.1155/2013/480713
Research Article

Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells

1Stem Cell Research Center, University of Pittsburgh School of Medicine, Bridgeside Point II, 450 Technology Drive, Pittsburgh, PA 15219, USA
2Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Bridgeside Point II, 450 Technology Drive, Pittsburgh, PA 15219, USA

Received 13 September 2012; Revised 4 December 2012; Accepted 22 December 2012

Academic Editor: Norman Jaffe

Copyright © 2013 Xiaodong Mu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [4 citations]

The following is the list of published articles that have cited the current article.

  • Xiaodong Mu, Bolat Sultankulov, Riddhima Agarwal, Adel Mahjoub, Trevor Schott, Nicholas Greco, Johnny Huard, and Kurt Weiss, “Chick Embryo Extract Demethylates Tumor Suppressor Genes in Osteosarcoma Cells,” Clinical Orthopaedics and Related Research®, 2013. View at Publisher · View at Google Scholar
  • Christopher G. Kanakry, Sudipto Ganguly, Marianna Zahurak, Javier Bolanos-Meade, Christopher Thoburn, Brandy Perkins, Ephraim J. Fuchs, Richard J. Jones, and Allan D. Hess, “Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide,” Science Translational Medicine, vol. 5, no. 211, 2013. View at Publisher · View at Google Scholar
  • Monica Cojoc, Katrin Mäbert, Michael H. Muders, and Anna Dubrovska, “A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms,” Seminars in Cancer Biology, 2014. View at Publisher · View at Google Scholar
  • Emmy D.G. Fleuren, Yvonne M.H. Versleijen-Jonkers, Melissa H.S. Roeffen, Gerben M. Franssen, Uta E. Flucke, Peter J. Houghton, Wim J.G. Oyen, Otto C. Boerman, and Winette T.A. van der Graaf, “Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models,” International Journal of Cancer, 2014. View at Publisher · View at Google Scholar