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Sarcoma
Volume 2013 (2013), Article ID 485483, 5 pages
http://dx.doi.org/10.1155/2013/485483
Clinical Study

The Use of Radiation Therapy in the Management of Selected Patients with Atypical Lipomas

1Harvard Radiation Oncology Program, Boston, MA 02215, USA
2Flushing Radiation Oncology Services, Queens, NY 11354, USA
3Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
4Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
5Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
6Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
7Department of Orthopaedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
8Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA

Received 28 August 2012; Revised 24 December 2012; Accepted 27 December 2012

Academic Editor: Charles Catton

Copyright © 2013 Josephine Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Objectives. Atypical lipomas are uncommon, slow-growing benign tumors. While surgery has been the primary treatment modality, we have managed some patients with radiation (RT) as a component of the treatment and have reported their outcomes in this study. Methods. A retrospective review of all cases of extremity and trunk atypical lipomas in The Sarcoma Database at the study institution was conducted. Results. Thirteen patients were identified. All patients underwent surgical resection at initial presentation and received pre- or postoperative radiation for subtotal resection ( ), local recurrence ( ), or progressive disease ( ). The median total radiation dose was 50 Gy. Median followup was 65.1 months. All patients treated with RT remained free of disease at the last followup. No grade 3 or higher late toxicity from radiation was observed. No cases of tumor dedifferentiation occurred. Conclusion. For recurrent or residual atypical lipomas, a combination of reexcision and RT can provide long-term local control with acceptable morbidity. For recurrent tumors, pre-op RT of 50 Gy appears to be an effective and well-tolerated management approach.