Research Article
Sporadic versus Radiation-Associated Angiosarcoma: A Comparative Clinicopathologic and Molecular Analysis of 48 Cases
Table 1
Summary of clinical features in radiation-associated angiosarcoma (RAA) patients.
| Case no. | Sex | Primary Dx | Age 1° Dx | Rx | RT dose (Gy) | Interval to RAA (mos) | RAA Tx | Status | Interval to death or last f/u (mos) |
| 1 | F | L breast CA | 50 | L/RT/Raloxifene | 60 | 37 | Gem, taxotere/M | DOD | 6.1 | 2 | F | L breast CA | 57 | L/RT | 64.6 | 89 | Adria, ifos/M (bil) | A-NED | 41.3 | 3 | F | L breast CA | 70 | L/RT | 60 | 63 | M/taxol | A-NED | 33.2 | 4 | F | R breast CA | 50 | L/RT | 61 | 57 | Adria, ifos/M | A-NED | 102.0 | 5 | F | R breast CA | 74 | L/RT/Tm | 52 | 84 | Vinb, actin-D/M | A-NED | 52.2 | 6 | F | R breast CA | 53 | L/C/RT/Tm | 64.6 | 93 | M (bil)/Adria, ifos | A-NED | 23.5 | 7 | F | L breast CA | 51 | L/C/RT | 54 | 141 | M/Adria, ifos/RT/Adria, ifos | A | 2.8 | 8 | F | SCC, R Cheek | 68 | WLE/RT | 70.2 | 78 | WLE/RT (palliative) | DOD | 11.0 | 9 | M | Seminoma | 26 | WLE/RT | Co × 6 wks | 419 | Ifos/WLE/RT (63 Gy) | DOD | 39.2 | 10 | M | Prostate CA | 72 | WLE/RT | 72 | 120 | WLE | D | 10.2 | 11 | F | Hodgkin’s lymphoma | 16 | C/total nodal RT | NA | 387 | Adria, ifos/amputation | DOD | 15.1 |
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CA: carcinoma, SCC: squamous cell carcinoma, L: lumpectomy, RT: radiation therapy, C: chemotherapy, Gem: gemcitabine, Adria: adriamycin, Ifos: ifosfamide, Tm: tamoxifen, M: mastectomy, WLE: wide local excision, D: dead, DOD: dead of disease, A: alive, A-NED: alive-no evidence of disease.
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