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Sarcoma
Volume 2013 (2013), Article ID 982784, 6 pages
http://dx.doi.org/10.1155/2013/982784
Research Article

Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI?

1Department of Orthopaedic Surgery, Markey Cancer Center, University of Kentucky, 740 S. Limestone Avenue, Lexington, KY 40536, USA
2Department of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
3Department of Orthopaedic Surgery, Duke Cancer Center, Duke University, Durham, NC 27710, USA

Received 13 September 2013; Revised 28 October 2013; Accepted 4 November 2013

Academic Editor: Cyril Fisher

Copyright © 2013 Patrick W. O'Donnell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Doyle, A. K. Pang, M. V. Miller, and J. G. French, “Magnetic resonance imaging of lipoma and atypical lipomatous tumour/well-differentiated liposarcoma: observer performance using T1-weighted and fluid-sensitive MRI,” Journal of Medical Imaging and Radiation Oncology, vol. 52, no. 1, pp. 44–48, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. F. El Ouni, H. Jemni, A. Trabelsi et al., “Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data,” Orthopaedics & Traumatology, Surgery & Research, vol. 96, no. 8, pp. 876–883, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. M. Lee, H. W. Chung, M. J. Shin et al., “Musculoskeletal magnetic resonance imaging suggesting the possibility of liposarcoma: correlation between radiologists' certainty of diagnosis and pathology results,” Journal of Computer Assisted Tomography, vol. 35, no. 4, pp. 512–516, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. K. N. O'Regan, J. Jagannathan, K. Krajewski et al., “Imaging of liposarcoma: classification, patterns of tumor recurrence, and response to treatment,” American Journal of Roentgenology, vol. 197, no. 1, pp. W37–W43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Billing, F. Mertens, H. A. Domanski, and A. Rydholm, “Deep-seated ordinary and atypical lipomas : histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall,” Journal of Bone and Joint Surgery B, vol. 90, no. 7, pp. 929–933, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. H. S. Kim, J. Lee, S. Y. Yi et al., “Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy,” BMC Cancer, vol. 9, article 205, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. D. Rozental, L. D. Khoury, R. Donthineni-Rao, and R. D. Lackman, “Atypical lipomatous masses of the extremities: outcome of surgical treatment,” Clinical Orthopaedics and Related Research, no. 398, pp. 203–211, 2002. View at Scopus
  8. C. A. Smith, S. R. Martinez, W. H. Tseng et al., “Predicting survival for well-differentiated liposarcoma: the importance of tumor location,” Journal of Surgical Research, vol. 175, no. 1, pp. 12–17, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. P. Dei Tos, “Liposarcoma: new entities and evolving concepts,” Annals of Diagnostic Pathology, vol. 4, no. 4, pp. 252–266, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. C. M. Gaskin and C. A. Helms, “Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses,” American Journal of Roentgenology, vol. 182, no. 3, pp. 733–739, 2004. View at Scopus
  11. J. Cohen, “A coefficient of agreement for nominal scales,” Educational and Psychological Measurement, vol. 20, pp. 37–46, 1960.
  12. D. J. Solomon, “The rating reliability calculator,” BMC Medical Research Methodology, vol. 4, article 11, 2004.
  13. C. H. Gerrand, J. S. Wunder, R. A. Kandel et al., “Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence,” Journal of Bone and Joint Surgery B, vol. 83, no. 8, pp. 1149–1155, 2001. View at Scopus
  14. M. Brisson, T. Kashima, D. Delaney, et al., “MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification,” Skeletal Radiology, vol. 42, no. 5, pp. 635–647, 2013.
  15. K. Thway, R. Flora, C. Shah, D. Olmos, and C. Fisher, “Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors,” American Journal of Surgical Pathology, vol. 36, no. 3, pp. 462–469, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Grimer, I. Judson, D. Peake, and B. Seddon, “Guidelines for the management of soft tissue sarcomas,” Sarcoma, vol. 2010, Article ID 506182, 15 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus