Table 1: Demographic and clinical characteristics of treated and untreated metastatic STS patients.

CharacteristicTotal ( )Treated patients ( )Untreated patients ( )

Age at treatment, (%)
 Mean (SD)61 (16)58 (14)63 (17)0.0031
 Median (range)62 (18, 91)58 (19, 90)65 (18, 91)0.0005
 <65203 (60)109 (63) 94 (50)<0.0001
 65–7576 (21)42 (24)34 (18)
 ≥7584 (23)23 (13)61 (32)
Gender, (%)
 Female175 (48)70 (40)105 (56)0.0035
 Male188 (52)104 (60)84 (44)
BMI, (%)
 Mean (SD)28.1 (6.3)28.5 (5.9)27.8 (6.8)0.2742
 Median (range)26.8 (15.4, 52.1)27.5 (17.1, 49.5)26.4 (15.4, 52.1)0.0624
 Underweight6 (2)3 (2) 3 (2)0.1270
 Normal weight104 (31)43 (25)61 (37)
 Overweight126 (37)70 (40)56 (34)
 Obese 103 (30)57 (33)46 (28)
 Missing24 1 23
Stage at diagnosis*, (%)
 I19 (8)12 (10)7 (6)0.1253
 II19 (8)9 (7) 10 (9)
 III56 (24)35 (29)21 (18)
 IV142 (60)65 (54)77 (67)
 Missing127 53 74
Cell morphology, (%)
 Leiomyosarcoma104 (29)50 (29)54 (29)
 Liposarcoma40 (11)20 (11)20 (11)
 Synovial Sarcoma12 (3)9 (5)3 (2)
 Other STS**207 (57)95 (55)112 (59)
Tumor grade, (%)
 124 (12)11 (10)13 (13)0.8523
 233 (16)19 (18)14 (14)
 3142 (69)74 (69)68 (69)
 4+8 (4)4 (4)4 (4)
 Missing156 66 90
Tumor type, (%)
 Resectable105 (61)51 (50)54 (61)0.8543
 Unresectable68 (39)34 (40)34 (39)
 Missing190 89101
Baseline ECOG, (%)
 059 (20)30 (22)29 (18)0.0034
 1153 (52)79 (49)74 (47)
 2+84 (28)25 (19)59 (36)
 Missing67 40 27
ECOG after first-line treatment, (%)
 017 (15)17 (15)
 169 (59)69 (59)
 2+30 (26)30 (26)
 Missing58 58
Primary site
 Head and neck14 (8)
 Lung9 (5)
 Liver3 (2)
 Trunk and viscera25 (14)
 Retroperitoneal33 (19)
 Extremity58 (33)
 Other29 (17)
 Missing 3 (2)

SD: standard deviation, BMI: body mass index, and ECOG: Eastern Cooperative Oncology Group Performance Status. : significance value by Chi-square test.
The stage of disease for each patient is consistent with the descriptions of the AJCC7 classifications of disease.
Other STS include angiosarcoma of soft tissue, alveolar rhabdomyosarcoma, alveolar soft part sarcoma, fibrosarcoma, Kaposi sarcoma, PNET, pleomorphic rhabdomyosarcoma, clear-cell sarcoma of soft tissue, malignant fibrous histiocytoma, myxofibrosarcoma, malignant phyllodes cystosarcoma, embryonal rhabdomyosarcoma, extraskeletal Ewing tumor, extraskeletal myxoid chondrosarcoma, osteosarcoma, malignant ossifying fibromyxoid tumor, malignant peripheral nerve sheet tumor, hemangiopericytoma, and sarcoma NOS.
Primary sites were captured through chart reviews for the treated patient cohort ( ) only. Chart reviews were not conducted for the untreated patient cohort ( ).