Epidemiology, Treatment Patterns, and Outcomes of Metastatic Soft Tissue Sarcoma in a Community-Based Oncology Network
Table 1
Demographic and clinical characteristics of treated and untreated metastatic STS patients.
Characteristic
Total ()
Treated patients ()
Untreated patients ()
Age at treatment, (%)
Mean (SD)
61 (16)
58 (14)
63 (17)
0.0031
Median (range)
62 (18, 91)
58 (19, 90)
65 (18, 91)
0.0005
<65
203 (60)
109 (63)
94 (50)
<0.0001
65–75
76 (21)
42 (24)
34 (18)
≥75
84 (23)
23 (13)
61 (32)
Gender, (%)
Female
175 (48)
70 (40)
105 (56)
0.0035
Male
188 (52)
104 (60)
84 (44)
BMI, (%)
Mean (SD)
28.1 (6.3)
28.5 (5.9)
27.8 (6.8)
0.2742
Median (range)
26.8 (15.4, 52.1)
27.5 (17.1, 49.5)
26.4 (15.4, 52.1)
0.0624
Underweight
6 (2)
3 (2)
3 (2)
0.1270
Normal weight
104 (31)
43 (25)
61 (37)
Overweight
126 (37)
70 (40)
56 (34)
Obese
103 (30)
57 (33)
46 (28)
Missing
24
1
23
Stage at diagnosis*, (%)
I
19 (8)
12 (10)
7 (6)
0.1253
II
19 (8)
9 (7)
10 (9)
III
56 (24)
35 (29)
21 (18)
IV
142 (60)
65 (54)
77 (67)
Missing
127
53
74
Cell morphology, (%)
Leiomyosarcoma
104 (29)
50 (29)
54 (29)
Liposarcoma
40 (11)
20 (11)
20 (11)
Synovial Sarcoma
12 (3)
9 (5)
3 (2)
Other STS**
207 (57)
95 (55)
112 (59)
Tumor grade, (%)
1
24 (12)
11 (10)
13 (13)
0.8523
2
33 (16)
19 (18)
14 (14)
3
142 (69)
74 (69)
68 (69)
4+
8 (4)
4 (4)
4 (4)
Missing
156
66
90
Tumor type, (%)
Resectable
105 (61)
51 (50)
54 (61)
0.8543
Unresectable
68 (39)
34 (40)
34 (39)
Missing
190
89
101
Baseline ECOG, (%)
0
59 (20)
30 (22)
29 (18)
0.0034
1
153 (52)
79 (49)
74 (47)
2+
84 (28)
25 (19)
59 (36)
Missing
67
40
27
ECOG after first-line treatment, (%)
0
17 (15)
17 (15)
1
69 (59)
69 (59)
2+
30 (26)
30 (26)
Missing
58
58
Primary site
Head and neck
14 (8)
Lung
9 (5)
Liver
3 (2)
Trunk and viscera
25 (14)
Retroperitoneal
33 (19)
Extremity
58 (33)
Other
29 (17)
Missing
3 (2)
SD: standard deviation, BMI: body mass index, and ECOG: Eastern Cooperative Oncology Group Performance Status. : significance value by Chi-square test. The stage of disease for each patient is consistent with the descriptions of the AJCC7 classifications of disease. Other STS include angiosarcoma of soft tissue, alveolar rhabdomyosarcoma, alveolar soft part sarcoma, fibrosarcoma, Kaposi sarcoma, PNET, pleomorphic rhabdomyosarcoma, clear-cell sarcoma of soft tissue, malignant fibrous histiocytoma, myxofibrosarcoma, malignant phyllodes cystosarcoma, embryonal rhabdomyosarcoma, extraskeletal Ewing tumor, extraskeletal myxoid chondrosarcoma, osteosarcoma, malignant ossifying fibromyxoid tumor, malignant peripheral nerve sheet tumor, hemangiopericytoma, and sarcoma NOS. Primary sites were captured through chart reviews for the treated patient cohort () only. Chart reviews were not conducted for the untreated patient cohort ().
