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Sarcoma
Volume 2014 (2014), Article ID 208786, 7 pages
http://dx.doi.org/10.1155/2014/208786
Research Article

Cell Senescence in Myxoid/Round Cell Liposarcoma

1Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, University of Gothenburg, Box 425, 40530 Gothenburg, Sweden
2Department of Oncology, Institute of Medical Sciences, University of Gothenburg, Blå stråket 2, 41345 Gothenburg, Sweden
3Department of Oncology, Institute of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden

Received 21 January 2014; Revised 22 May 2014; Accepted 23 May 2014; Published 24 June 2014

Academic Editor: Charles Catton

Copyright © 2014 Christina Kåbjörn Gustafsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma type and characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. Previous analysis of cell cycle regulatory proteins revealed a prominent expression of G1-cyclins, cyclin dependent kinases, and their inhibitors but very few cells progressing through the G1/S boundary. Here, we extend the investigation to proteins involved in cell senescence in an immunohistochemistry based study of 17 MLS/RCLS cases. Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1γ and IL8 receptor β. We conclude that MLS/RCLS tissues contain major populations of senescent tumor cells and this may explain the slow growth rate of this tumor type.