Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

Table 1

Pairwise Pearson correlation coefficients between log-transformed 𝐼𝐻𝐻, 𝑃𝑇𝐶𝐻1, 𝐺𝐿𝐼1, and 𝑆𝑀𝑂 expression in osteosarcoma samples and 𝑃 value for test of the null hypothesis that correlation is zero.

NoMetDx (𝑛=32)

Large tumors (𝑛=15)

Small tumors (𝑛=15)

logIHH

logPTCH1

logSMO

logGLI1

logIHH

logPTCH1

logSMO

logGLI1

logIHH

logPTCH1

logSMO

logGLI1

logIHH

1.00

0.44 (𝐏=𝟎.𝟎𝟏𝟏)

0.20; (𝑃=0.27)

0.34 (𝐏=𝟎.𝟎𝟓𝟔)

1.00

0.56 (𝐏=𝟎.𝟎𝟐𝟗)

0.05; (𝑃=0.86)

0.39; (𝑃=0.15)

1.00

0.37; (𝑃=0.18)

0.28; (𝑃=0.31)

0.34; (𝑃=0.21)

logPTCH1

1.00

0.52 (𝐏=𝟎.𝟎𝟎𝟐)

0.61 (𝐏=𝟎.𝟎𝟎𝟎𝟐)

1.00

0.43; (𝑃=0.11)

0.44; (𝑃=0.10)

1.00

0.53 (𝐏=𝟎.𝟎𝟒)

0.70 (𝐏=𝟎.𝟎𝟎𝟒)

logSMO

1.00

0.45 (𝐏=𝟎.𝟎𝟎𝟗)

1.00

0.24; (𝑃=0.40)

1.00

0.56 (𝐏=𝟎.𝟎𝟑)

logGLI1

1.00

1.00

1.00

Bold text indicates statistically significant positive correlations.
Two patients have missing tumor size information.