Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

Table 2

Results of DFS analysis by Cox Proportional Hazards model in no metastasis at diagnosis group (𝑛=32) for IHH.

Prognostic factor	Univariate				Multivariate*
	HR	95% CI		𝑃 value	HR	95% CI		𝑃 value
IHH
High versus low	2.66	0.84	8.40	0.0948	6.43	0.71	57.97	0.0970
Size
>9 cm versus ≤9 cm	3.52	1.06	11.67	0.0394	22.81	2.22	234.02	0.0085
Necrosis
>90% versus ≤90%	0.71	0.21	2.35	0.5716	0.53	0.13	2.14	0.3733
Gender
Male versus female	1.39	0.44	4.36	0.5795	0.22	0.02	2.25	0.1998
Age (years)	1.02	0.99	1.05	0.1676	1.03	0.99	1.07	0.0965

∗Firth correction to handle small sample sizes.