Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome

Table 3

Therapies used for patients with recurrence in the YA cohort without metastatic disease at diagnosis.

Disease Description	Primary therapy received	Childhood MAP regimen achieved?	Histological response; to primary therapy	Progression on primary therapy	Secondary therapy received	Progression on subsequent therapy	Time to recurrence in years	Type of recurrence	Survival time in years	Current status
Chondroblastic osteosarcoma of the pelvis	MAPIE,; proton beam therapy	No	N/A	No	Gem, Tax, wedge resection, MTP-PE, bevacizumab, zoledronic acid	Yes	0.31	(1) Lung; (2) local progression with chest wall metastasis	2.37	DOD
Osteoblastic osteosarcoma of the distal femur	Neoadj/adj MAPI, resection	Yes	Poor	No	Inhaled chemotherapy, vaccine trial	Yes	1.10	(1) Lung, lymph nodes; (2) apex of heart, mitral valve	2.63	DOD
Osteoblastic osteosarcoma of proximal fibula	Neoadj/adj MAPIE, resection	Yes	Unknown	No	Amputation, serial lung excisions, IEP, trimetrexate trial	Yes	1.60	(1) Local; (2) multiple lung nodules bilaterally	3.98	DOD
Osteoblastic osteosarcoma of distal femur	VP-16, IE, AP, resection	No	Good	No	MAP, amputation, gem, phase I ASAP, phase I Ski-606	Yes	0.20	(1) Local; (2) lung, hip, and pelvis	4.05	DOD
Osteosarcoma of unknown histology in proximal humerus	Neoadj/adj MAP, forequarter amputation	No	Poor	Yes	IE	Yes	0.14	Lung	1.84	DOD
Osteoblastic osteosarcoma of distal tibia	Neoadj/adj MAP,; Resection	Yes	Good	No	Wedge resection, IE	No	0.87	Lung	3.18	NED
Chondroblastic osteosarcoma of the chest wall	Neoadj/adj MAP, resection	No	Good	Yes	Unk	Unk	0.50	Local	3.18	Unk
Chondroblastic osteosarcoma of the chest wall	Resection, adj MAP	No	N/A	No	AI, thoracotomy, neurosurgery, neuroradiation	Yes	1.46	(1) Local; (2) lung and brain	4.30	DOD
Osteoblastic osteosarcoma of the proximal tibia	Resection,; Adj AP	No	N/A	No	AI, Above-knee amputation, AP, wedge resection, rapamycin	Yes	0.61	(1) Local; (2) proximal fibula; (3) lung	2.90	DOD
Osteosarcoma unclassifiable subtype, pelvis	MAID, radiation therapy	No	N/A	Yes	AP	Yes	0.00	Spine and femoral head	1.15	DOD
Osteoblastic osteosarcoma of proximal tibia	Neoadj/adj MAI,; resection	No	Poor	No	Gem, Tax, imatinib, P, Doxil, local resection, wedge resection	Yes	0.33	(1) Lung; (2) local	2.35	DOD
Periosteal osteosarcoma of proximal tibia	Neoadj MAP, resection	No	Poor	No	Local radiation, resection, IE, wedge resection	No	1.08	(1) Local,; (2) lung	4.80	NED
Giant cell osteosarcoma in sacral spine	MAP, radiation therapy, IE, temozolomide	No	N/A	Yes	Temozolomide radiation, IE, denosumab, pazopanib, palliative surgery	Yes	1.42	(1) Local; (2) rib; (3) acetabulum	3.38	AWD

M: methotrexate; A: doxorubicin; P: cisplatin; I: ifosfamide; E: etoposide; gem: gemcitabine; Tax: Taxotere; MTP-PE: mifamurtide; Unk: unknown; Neoadj: neoadjuvant; Adj: adjuvant; NED: no evidence of disease; DOD: died of disease; AWD: alive with disease. Time to recurrence was measured from end therapy date to date of recurrence. Survival time was measured from date of diagnosis to date of death or censored date. Recurrences are numbered in the order of discovery.