Table 1: Comparison of published reports detailing characteristics of patients with brain metastases from primary osteosarcoma.

Case authorAge, sex Primary sitePrimary treatmentIB MoMetastatic siteMetastatic treatmentOS MoSpecial aspects

Rabah et al., 2013 [13]10 FRight humerus(None)0aRight frontal lobeChemo, WBRT14Cerebral metastasis on presentation

Onodera et al., 2012 [14]14 FLeft femurSurgery, chemo12Right parietal lobeSRNRNo active pulmonary metastasis

Chou et al., 2011 [4]
15–58, M (4)
NRNRNRSingle cerebrum (3); multiple (2)SR + RTD

Flannery et al., 2010 [15]
17–37, M (3)
Pelvis, femur, humerus ChemoNR1 single, 2 multiple GKSRS36–84Gamma knife radiosurgery as therapy

Salvati et al., 2010, 1998 [2, 9]
11–60, M (5)
Femur, tibia NR0–110Frontal (5), multiple (3), parietal, temporal SR + WBRTNR

Niazi et al., 2009 [20]16 MRight femur(None)0aLeft cerebellumSR6 daysPosterior fossa hemorrhage on presentation

Kebudi et al., 2005 [3]
12–16, M (3)
NRNR3–27Single (3),
multiple (2)
None (2);
RT + chemo (3)
1–6Literature review included in original study

Yonemoto et al., 2003 [18]14 FRight femurSR + chemo26Tumor infiltration outside the bone cortexSR + WBRTAlive at 72N/a

Paulino et al., 2003 [17]
11–19, M (4)
Femur (2), humerus, tibia, scapulaNR10–48Frontal (3), occipital (1), multiple (1) SR, chemo, WBRT, None (2)1–10

Weil et al., 2005 [21] 26 MRight tibiaChemo + SR36Skull and brain metastasisSR4Patient refused chemo or RT for brain met treatment

Bouffet et al., 1997 [16]

9-17, M
NRNR12–15Supratentorial (2)None
RT (2)
2–4

Wroński et al., 1995 [5]
7–26, M (2)
Femur (3), maxilla humerusNR18–63Temporal, parietal/occipital (3), posterior fossa SR2.4–13WBRT was given to select patients (unspecified)

Chang et al., 1994 [22]20 MBilateral femur(None)0aRight frontal lobeSR + RT5Early metastasis, multifocal

Marina et al., 1993 [19]3 MLeft humerusSR, chemo4Temporal and left parietal ChemoAlive at 108Additional review of 13 patients

Wexler et al., 1993 [23]10 FRight femurSR, chemo51Left parietal and occipital SR, WBRTAlive at 120N/a

Niedeggen et al., 1990 [24]7 MLeft femurSR, chemo76Right parietal lobeSR, RTAlive at 13Histological findings included

Baram et al., 1988 [25]
8–15, M (2)
NRChemo ± SR 2–46Frontal (2), multiple (1), NR (2)Chemo ± SR DIncidence, clinical, and radiological findings and management

Lewis, 1988 [26]15 FRight humerusLocal radiotherapy 0cLeft frontal lobe, left corpus callosumChemo 0Brain lesions discovered upon autopsy

Ozarda et al., 1983 [27]23 MRight femurNR8Right occipital lobe Chemo + RTNRBone scintigraphy usage

Danziger et al., 1979 [28]
18–20, F (3)
Right femur (3)SR, chemo, RT6–24Temporal/occipital, frontoparietal, parietalChemo + RT
SR, none
D (2), NR

IB: interval to brain metastasis (mo); OS: overall survival in months; M: male; F: female; chemo: chemotherapy; SR: surgical resection; GKSRS: Gamma knife stereotactic radiosurgery. WBRT: whole brain radiotherapy; RT: radiotherapy; D: death prior to treatment; NR: not reported; abrain metastasis at initial presentation; balive at last follow-up without recurrence; cbrain metastasis at autopsy.