Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Table 4

Comparison of published reports detailing characteristics of patients with brain metastases from fibroblastic and fibrohistiocytic tumors.

Case author	Age, sex	Tumor type; primary site	Primary treatment	IB Mo	Metastatic site	Metastatic treatment	OS Mo	Special aspects/; Bone versus soft tissue origin
Wu et al., 2012 [59]	32 F	MFH; maxillary sinus	SR (radical); RT	24	Right parietal	SR; WBRT	25	Origin: softtissue
Graber et al., 2011 [60]	56 M	MFH; aorta	RT; chemo	0^a	Multiple	Biopsy	?	Cystic brain lesion; mimics neurocysticercosis; Origin: softtissue (aorta)
Louis et al., 2007 [58]	38 M	MFH; mandible	SR; RT	12	Extensive, unspecified^a	None	12	MFH associated w/a Marjolin’s ulcer; Origin: bone
Kousar et al., 2009 [70]	20 F	AFS; mandible	SR; RT	6	Multiple	None	15	Origin: odontic = bone
Hoshi et al., 2008 [63]	45 M	MFH; forearm	SR; RT; chemo	48	Multiple, parietal, and occipital	Chemo, WBRT	60	Previous lung/bone metastasis at 3 yrs; SC metastasis at 5 yrs; Origin: softtissue
Erguvan-Önal et al., 2004 [71]	45 F	FS; thigh	SR; RT	2	Right frontal	SR	7	Epitheloid transformation; Origin: softtissue
Rogers and Whelan, 2000 [64]	𝑁 = 4; 40–54, M (2)	MFH; humerus, femur, knee, pelvis	Chemo; RT	4–148	Multiple (2), single (2)	RT (2), none (2)	7–153	Previous systemic metastasis in all; Origin: bone
Ogose et al., 1999 [33]	𝑁 = 5; 40–66, M (2)	Thigh (3), back	NR	0–10	Frontal (3), parietal, temporal	None (2), SR (2)	0.5–16	Origin: unknown
Salvati et al., 2010 [2]	𝑁 = 2; 21–30, M	MFH; heart, heart	RT, chemo	19–21	Frontal	SR	9–11	Origin: soft tissuee
I. A. Auer and R. N. Auer, 1998 [72]	43 M	DFS; abdomen	NR	72	Tempro-parietal	SR	144	Brain recurrence at 144; prior skin, lung metastasis
Kim et al., 1997 [69]	18 F	MFS; heart	SR, RT, chemo	24	Occipital, cerebellum	SR, WBRT	50	Origin: softtissue
Jeffery and Ford, 1995 [67]	67 F	FS; abdominal wall	SR	60	Right parietal lobe	None	61	ICH; previous bone metastasis; origin: sof-tissue
Onoda et al., 1990 [73]	45 M	DFS; upper arm	SR	76	Multiple	none	84	Lungs, skin
Wroński et al., 1995 [5]	𝑁 = 3; 28–67, M (2)	MFH; scalp, thigh, pul.a.	NR	3–27	Occipital, parietal, posterior fossa	SR	10.2^b–65^b	Lungs
Bindal et al., 1994 [38]	𝑁 = 3; 25–40, M (2)	MFH; trunk, heart, shoulder		12–2218	Right parietal, multiple (2)	SR, WBRT	2.3^b–11.8^b	Prev lungs
Lewis, 1988 [66]	36–53, M	DFS; clavicular; MFH, scapular	SR; RT, chemo	36–312	Multiple	SR; none^c	313, LTF	Origin: softtissue
Takamiya et al., 1986 [65]	43 M	FS; pectoralis major	SR	1	Right frontoparietal	SR, RT, WBRT	Alive at 13	Origin: sof-tissue
Zucker et al., 1978 [61]	42 F	FS; liver?	None	24	Pons	none	24	Origin: softtissue
Dal Canto and Valsamis, 1973 [62]	60 F	FS; renal capsule	None	0	Pons	None	0	Origin: softtissue
Gercovich et al., 1975 [42]	𝑁 = 2; 31–52 M	FS; lip, retroperitoneal	Chemo	3–55	Frontal, parietal	NR	NR	Origin: softtissue
Ho, 1979 [68]	70 F	FS; thigh	SR (partial)	12	Leptomeninges, cortical	None^c	NR	Origin: softtissue

AFS: ameloblastic fibrosarcoma; FS: fibrosarcoma; DFS: dermatofibrosarcoma; IB: interval to brain metastasis (mo); OS: overall survival in months; M: male; F: female; chemo: chemotherapy; GKSRS: Gamma knife stereotactic radiosurgery; MFS: myxofibrosarcoma; ICH: intracerebral hemorrhage on presentation; SR: surgical resection; WBRT: whole brain radiotherapy; RT: radiotherapy; D: death prior to treatment; LTF: lost to follow-up; MFH: malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma); NR: not reported.
^aBrain metastasis diagnosed at presentation; ^bsurvival after craniotomy; ^cbrain metastasis reported at autopsy.