Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Table 7

Summary of cases of alveolar soft part sarcoma with brain metastases as reported in previous published series.

Case Author	𝑁	Age, sex	Primary site	Primary treatment	IB Mo	𝑁 with BM	Metastatic treatment*	OS* (Mo)	Special aspects
Daigeler et al., 2008 [130]	11	19–24, M (7)	Thigh (2), lower leg (2), thoracic wall (2), upper arm (2), forearm (1), Foot (1)	SR; chemo with RT	78 months (5–156)	3/11	SR, RT	73% of patients are still alive at follow-up with no evidence of disease	Localized disease, complete resection. And adjuvant radiation within 2 years had favorable outcome
Kayton et al., 2006 [138]	20	16.5; 6–24,; M (10)	Thigh (8), trunk (6), Retroperito. (2), scalp, neck, forearm, calf	SR, chemo, RT	36 months	2/20	SR	Follow-up: patients were alive after mean 22 years (4–32 years)	Tumors, 5 cm were associated with longer progression-free survival
Park et al., 1999 [139]	6	24.5 (17–35); (2) M	Femur (3), fibula (2), ilium	SR, chemo, RT	10–12 months	2/6	N/A	Follow-up range of patients with no evidence of disease (7 mo.–8 yrs.)	ASPS arising in bone
Portera et al., 2001 [134]	74	26 (3–68); 49% male	Extremities (60%), trunk (20%), head and neck (12%), Retroper. (8%)	SR; RT; chemo	5–24 months	14/74	Chemo	Median was 41 months for patients w/o metastasis and 40 months with metastasis
Bindal et al., 1994 [38]	2	40–48; 1 male	Thigh, rectum	SR	1–15 months	2/2	SR	Still alive after 24.7 and 16.4 months
Flannery et al., 2010 [15]	2	42.4 (14–74)	Leg, gluteal	Chemo and SR	30–48 months	2/2	SR	Survived from 5 to 7 years after surgery with no evidence of disease; 31–36 months after metastasis
Salvati et al., 2010 [2]	3	35 (19–61); males	Thigh (100%)	SR	24–58 months	3/3		Alive from 15 to 24 months after SR with no evidence of disease
Wroński et al., 1995 [5]	2	7–14; 1 male	Thigh, tongue	SR	23 months	2/2	SR	Alive 2.7–23 months SR with no evidence of disease
Chou et al., 2011 [4]	4	25 (17–33); M	NR	SR and RT	14.53 months	4/4	SR and RT	3 dead; 1 still alive

∗Some results are reported for an entire series of ASPS patients, and not necessarily only those with BM; ASPS: alveolar soft part sarcoma; BM: brain metastasis; IB: interval to brain metastasis (mo); OS: overall survival in months; M: male; F: female; chemo: chemotherapy; SR: surgical resection; GKSRS: Gamma knife stereotactic radiosurgery; ICH: intracerebral hemorrhage on presentation; WBRT: whole brain radiotherapy; RT: radiotherapy; D: death prior to treatment; NR: not reported; UK: unknown; ^asurvival after craniotomy.