Cost-Effectiveness of Pazopanib in Advanced Soft Tissue Sarcoma in the United Kingdom

Table 7

Calculation of costs of posttreatment anticancer therapy.

Treatment	Medication cost^a						Administration costs^b
	Mg per tab or vial	Cost per tab or vial, £	Cost per mg, £	Cost per administration, £	Expected days of use per course	Cost per course of therapy, £	Cost per administration, £	Expected days of use per course	Cost per course of therapy, £	Total cost per course; of therapy, £
Cyclophosphamide	500	6	0	30	6.14	187	330	6.14	2,027	2,214
Dacarbazine	1,000	32	0	68	3.35	229	205	3.35	686	915
Doxorubicin	200	275	1	181	2.85	515	205	2.85	583	1,098
Etoposide	100	12	0	13	30.68	400	205	30.68	6,280	6,681
Etoposide + ifosfamide (+mesna)
Etoposide	100	12	0	13	26.30	343	205	26.30	5,383	—
Ifosfamide	1,000	44	0	217	15.78	3,430	302	15.78	1,539	—
Mesna	400	4	0	46	15.78	725	—	15.78	—	—
Total	—	—	—	—	—	4,499	—	—	6,922	11,421
Gemcitabine	1,500	214	0.14	197	13.57	2,674	205	13.57	2,778	5,451
Gemcitabine + docetaxel (+lenograstim)
Gemcitabine	1,500	214	0.14	185	8.90	1,643	205	8.90	1,821	—
Docetaxel	140	720	5.14	676	4.45	3,007	—	4.45	—	—
Lenograstim	0.263	62.54	238	64	31.14	1,988	0.57	31.14	18	—
Total	—	—	—	—	—	6,639	—	—	1,839	8,478
Ifosfamide (+mesna)
Ifosfamide	1,000	44	0	217	15.78	3,430	302	15.78	4,769	—
Mesna	400	4	0	46	15.78	725	—	15.78	—	—
Total	—	—	—	—	—	4,156	—	—	4,769	8,924
Sorafenib	200	27	0	71	114.37	8,096	12	4.08	49	8,145
Sunitinib	12.5	28	2	99	65.33	6,489	12	1.56	19	6,508
Temozolomide	250	136	0.54304	109	23.67	2,570	12	0.85	10	2,580
Trabectedin	1	1,366	1,366	3,167	3.40	10,768	330	3.40	1,123	11,891

Tab: tablet; aunit costs of medications based on British National Formulary [32, 35]; ^bfacility costs for administration of intravenous therapies are based on a weighted average of the outpatient, day case, and other 2010/2011 NHS Reference Costs for delivery of a chemotherapy cycle (SB12Z deliver simple parenteral chemotherapy at first attendance, and SB14Z deliver complex chemotherapy, including prolonged infusional treatment at first attendance for infusion of more than 24 hours) [35]. Assume dispensing costs of oral medications are based on the cost of a community pharmacist (15 minutes) [34].