Table 8: Random effects estimates of the probabilities of grade 3–5 AEs for each comparator based on Freeman-Tukey transformation (%)a.

Description of adverse event (% [SE])PazopanibBSCTrabectedinIfosfamide 3 g/m2GEM/DOC

General
 Alopecia0.1 (6.4)0.2 (9.0)0.5 (13.5)64.6 (15.6)0.5 (14.3)
 Asthenia/fatigue 13.9 (6.4)5.2 (9.0)6.9 (15.5)5.2 (9.0)3.0 (14.3)
 Hypertension 6.8 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
 Myalgia/muscle pain2.3 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
 Neurotoxicity/peripheral sensory neuropathy0.6 (6.4)1.2 (9.0)1.2 (9.0)6.0 (15.6)0.5 (14.3)
 Edema2.3 (6.4)2.0 (9.0)4.1 (16.7)2.0 (9.0)19.4 (14.3)
Liver toxicity
 ALT elevation9.9 (6.5)3.6 (9.0)43.2 (12.5)1.2 (9.0)1.2 (9.0)
 AST elevation8.2 (6.5)2.0 (9.0)35.3 (8.2)1.2 (9.0)0.5 (14.3)
Cardiovascular
 Cardiac toxicity0.1 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
 Left ventricular dysfunction 1.9 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
Pulmonary
 Dyspnea6.4 (6.4)6.0 (9.0)4.2 (8.7)6.0 (9.0)0.5 (14.3)
 Pleural effusion2.3 (6.4)0.2 (9.0)0.2 (8.7)0.2 (9.0)0.5 (14.3)
 Pneumothorax2.3 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
 Pulmonary toxicity0.1 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)9.2 (14.3)
Gastrointestinal
 Decreased appetite/anorexia6.0 (6.4)0.2 (9.0)1.5 (7.3)0.2 (9.0)0.2 (9.0)
 Diarrhea4.8 (6.4)1.2 (9.0)0.9 (7.3)1.2 (9.0)1.2 (9.0)
 Nausea/vomiting 6.8 (6.4)2.8 (9.0)13.5 (5.6)18.3 (15.6)3.0 (14.3)
 Weight decreased 3.9 (6.4)0.2 (9.0)0.2 (9.0)0.2 (9.0)0.2 (9.0)
Hematologic abnormalities
 Febrile neutropenia0.1 (6.4)0.2 (9.0)5.3 (14.5)0.2 (9.0)0.2 (9.0)
 Anemia/hemoglobin6.4 (6.4)2.0 (9.0)13.6 (9.9)20.7 (15.6)25.5 (14.3)
 Leucopenia1.4 (6.4)0.2 (9.0)43.2 (7.2)64.6 (15.6)23.5 (14.3)
 Neutropenia/neutrophils4.4 (6.4)0.2 (9.0)49.2 (8.7)50.0 (15.6)21.4 (14.3)
 Thrombocytopenia/low platelets3.9 (6.4)0.2 (9.0)15.7 (5.6)15.8 (15.6)39.8 (14.3)

AE: adverse event; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BSC: best supportive care; GEM/DOC: gemcitabine + docetaxel; SE: standard error.
SE on Freeman-Tukey transformation scale.
Note: if there is no information on AE then probability [SE] is assumed to be the same as placebo in PALETTE.