Comorbidity in Adult Bone Sarcoma Patients: A Population-Based Cohort Study
Table 2
Uni- and multivariate analyses of comorbidity and possible important prognostic factors for overall and disease-specific mortality in adult bone sarcoma patients .
(%)
Overall mortality
Disease-specific mortality
5-year (%)
HR (95% CI)
5-year (%)
HR (95% CI)
Univariate
Multivariate
Univariate
Multivariate
Age
1 year
—
—
1.03 (1.02-1.03)
1.03 (1.02–1.04)
—
1.01 (1.00–1.02)
1.02 (1.01–1.03)
Comorbidity
No
368 (81)
38
1
1
34
1
1
Mild
37 (8)
52
1.64 (1.08–2.49)
1.11 (0.71–1.75)
46
1.47 (0.90–2.40)
1.08 (0.63–1.86)
Moderate
27 (6)
52
2.03 (1.26–3.25)
1.64 (0.99–2.72)
37
1.29 (0.68–2.46)
1.20 (0.61–2.36)
Severe
21 (5)
62
2.25 (1.37–3.70)
1.35 (0.80–2.27)
43
1.79 (0.97–3.31)
1.28 (0.68–2.43)
Stage at diagnosis
Localized
387 (85)
35
1
1
28
1
1
Metastatic
66 (15)
80
3.97 (2.96–5.33)
2.01 (1.35–2.98)
79
5.55 (4.03–7.64)
2.12 (1.39–3.24)
Tumor size
1 cm
—
—
1.07 (1.04–1.09)
1.04 (1.02–1.07)
—
1.07 (1.05–1.10)
1.04 (1.01–1.07)
Soft tissue involvement
No
86 (19)
16
1
1
12
1
1
Yes
367 (81)
47
2.34 (1.60–3.40)
1.72 (1.16–2.56)
41
3.48 (2.05–5.90)
2.08 (1.20–3.62)
Grade
1
107 (24)
15
1
1
9
1
1
2
69 (15)
22
1.24 (0.76–2.01)
0.86 (0.52–1.42)
16
1.60 (0.81–3.17)
1.14 (0.57–2.29)
3
277 (61)
56
2.70 (1.92–3.78)
2.38 (1.61–3.51)
51
5.05 (3.06–8.33)
3.57 (2.04–6.23)
Histology
Ewing/osteosarcoma
176 (39)
55
1
1
53
1
1
Others
277 (61)
33
0.72 (0.56–0.92)
0.78 (0.55–1.11)
25
0.44 (0.33–0.59)
0.67 (0.44–1.01)
Surgery
Wide/radical
269 (60)
34
1
1
28
1
1
Intralesional/marginal
117 (26)
34
1.29 (0.96–1.74)
1.66 (1.21–2.28)
27
1.23 (0.86–1.77)
1.77 (1.20–2.60)
No
64 (14)
84
5.59 (4.09–7.65)
2.49 (1.66–3.72)
84
7.01 (4.97–9.89)
3.02 (1.94–4.68)
Chemotherapy
Curative
106 (23)
40
1
1
39
1
1
Palliative
29 (6)
97
6.71 (4.18–10.79)
1.63 (0.93–2.86)
97
5.63 (3.48–9.13)
1.40 (0.78–2.51)
No
318 (70)
37
1.22 (0.89–1.68)
1.16 (0.76–1.76)
29
0.83 (0.59–1.17)
1.21 (0.76–1.91)
Note: abbreviations: HR: hazard ratio, CI: confidence interval. Multivariate analyses adjusted mutually for age, comorbidity, stage at diagnosis, tumor size, soft tissue involvement, grade, histology type, surgery, and chemotherapy.
