Table 2: Uni- and multivariate analyses of comorbidity and possible important prognostic factors for overall and disease-specific mortality in adult bone sarcoma patients .


(%)
Overall mortality Disease-specific mortality
5-year (%)HR (95% CI)5-year (%)HR (95% CI)
UnivariateMultivariate UnivariateMultivariate

Age
 1 year1.03 (1.02-1.03)1.03 (1.02–1.04)1.01 (1.00–1.02)1.02 (1.01–1.03)
Comorbidity
 No368 (81)38113411
 Mild37 (8)521.64 (1.08–2.49)1.11 (0.71–1.75)461.47 (0.90–2.40)1.08 (0.63–1.86)
 Moderate27 (6)522.03 (1.26–3.25)1.64 (0.99–2.72)371.29 (0.68–2.46)1.20 (0.61–2.36)
 Severe21 (5)622.25 (1.37–3.70)1.35 (0.80–2.27)431.79 (0.97–3.31)1.28 (0.68–2.43)
Stage at diagnosis
 Localized387 (85)35112811
 Metastatic66 (15)803.97 (2.96–5.33)2.01 (1.35–2.98)795.55 (4.03–7.64)2.12 (1.39–3.24)
Tumor size
 1 cm1.07 (1.04–1.09)1.04 (1.02–1.07)1.07 (1.05–1.10)1.04 (1.01–1.07)
Soft tissue involvement
 No86 (19)16111211
 Yes367 (81)472.34 (1.60–3.40)1.72 (1.16–2.56)413.48 (2.05–5.90)2.08 (1.20–3.62)
Grade
 1107 (24)1511911
 269 (15)221.24 (0.76–2.01)0.86 (0.52–1.42)161.60 (0.81–3.17)1.14 (0.57–2.29)
 3277 (61)562.70 (1.92–3.78)2.38 (1.61–3.51)515.05 (3.06–8.33)3.57 (2.04–6.23)
Histology
 Ewing/osteosarcoma176 (39)55115311
 Others277 (61)330.72 (0.56–0.92)0.78 (0.55–1.11)250.44 (0.33–0.59)0.67 (0.44–1.01)
Surgery
 Wide/radical269 (60)34112811
 Intralesional/marginal117 (26)341.29 (0.96–1.74)1.66 (1.21–2.28)271.23 (0.86–1.77)1.77 (1.20–2.60)
 No64 (14)845.59 (4.09–7.65)2.49 (1.66–3.72)847.01 (4.97–9.89)3.02 (1.94–4.68)
Chemotherapy
 Curative106 (23)40113911
 Palliative29 (6)976.71 (4.18–10.79)1.63 (0.93–2.86)975.63 (3.48–9.13)1.40 (0.78–2.51)
 No318 (70)371.22 (0.89–1.68)1.16 (0.76–1.76)290.83 (0.59–1.17)1.21 (0.76–1.91)

Note: abbreviations: HR: hazard ratio, CI: confidence interval. Multivariate analyses adjusted mutually for age, comorbidity, stage at diagnosis, tumor size, soft tissue involvement, grade, histology type, surgery, and chemotherapy.