Research Article
Comorbidity in Adult Bone Sarcoma Patients: A Population-Based Cohort Study
Table 3
Patient characteristics by Charlson Comorbidity Index score
.
| | | (%) | Charlson Comorbidity Index score (%) | -value | | | 0 | 1 | 2 | 3+ |
| | Number | 453 (100) | 368 (81) | 37 (8) | 27 (6) | 21 (5) | | | Age (years) | | | | | | | | Median (range) | 46 (15–90) | 40 (15–90) | 62 (17–83) | 59 (17–81) | 64 (21–86) | <0.001 | | Sex | | | | | | | | Female | 179 (40) | 137 (37) | 20 (54) | 12 (44) | 10 (48) | | | Male | 274 (60) | 231 (63) | 17 (46) | 15 (56) | 11 (52) | 0.18 | | Year of diagnosis | | | | | | | | 1979–1988 | 131 (29) | 116 (32) | 10 (27) | 0 (0) | 5 (24) | | | 1989–1998 | 129 (28) | 103 (28) | 8 (22) | 12 (44) | 6 (29) | | | 1999–2008 | 193 (43) | 149 (40) | 19 (51) | 15 (56) | 10 (48) | 0.027 | | Stage at diagnosis | | | | | | | | Localized | 387 (85) | 321 (87) | 32 (86) | 18 (67) | 16 (76) | | | Metastatic | 66 (15) | 47 (13) | 5 (14) | 9 (33) | 5 (24) | 0.018 | | Tumor size (cm) | | | | | | | | Median (range) | 8 (1–30) | 8 (1–30) | 8 (2–30) | 7 (2–15) | 10 (3–23) | 0.14 | | Soft tissue involvement | | | | | | | | No | 86 (19) | 71 (19) | 5 (14) | 4 (15) | 6 (29) | | | Yes | 367 (81) | 297 (81) | 32 (86) | 23 (85) | 15 (71) | 0.51 | | Malignancy grade | | | | | | | | 1 | 107 (24) | 86 (23) | 11 (30) | 7 (26) | 3 (14) | | | 2 | 69 (15) | 55 (15) | 8 (22) | 4 (15) | 2 (10) | | | 3 | 277 (61) | 227 (62) | 18 (50) | 16 (59) | 16 (76) | 0.59 | | Histological type | | | | | | | | Ewing/osteosarcoma | 176 (39) | 149 (40) | 10 (27) | 9 (33) | 8 (38) | | | Others | 277 (61) | 219 (60) | 27 (73) | 18 (67) | 13 (62) | 0.40 | | Treatment | | | | | | | | Surgery | 389 (86) | 325 (88) | 30 (81) | 19 (70) | 15 (71) | 0.009 | | Type | | | | | | | | Resection | 257 (66) | 213 (66) | 19 (63) | 13 (76) | 12 (80) | | | Amputation | 130 (34) | 112 (34) | 11 (37) | 4 (24) | 3 (20) | <0.001 | | Margin | | | | | | | | Wide/radical | 269 (70) | 228 (70) | 19 (63) | 13 (76) | 9 (60) | | | Intralesional/marginal | 117 (30) | 96 (30) | 11 (37) | 4 (24) | 6 (40) | <0.001 | | Radiotherapy | 83 (18) | 71 (19) | 5 (14) | 3 (11) | 4 (19) | 0.63 | | Chemotherapy | 135 (30) | 119 (32) | 4 (11) | 8 (30) | 4 (19) | 0.005 | | Curative | 106 (79) | 98 (82) | 2 (50) | 3 (38) | 3 (75) | | | Palliative | 29 (21) | 21 (18) | 2 (50) | 5 (63) | 1 (25) | 0.012 |
|
|
Note: tumor size: 38 missing. Type of surgery: 2 missing. Surgical margin: 3 missing.
|
