Research Article

Fluorescence In Situ Hybridization for MDM2 Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center

Table 3

Comparison of patient and tumor characteristics in cases with concordance or discrepancies of histology and FISH.

Histological diagnosisMDM2 amplifiedTotalSex of patientsMedian age (years)Median size of tumor (cm)Classical sites for WDL/DDL (intra-abdominal or inguinal)Review casesCore biopsiesResection specimens

Benign (definite/provisional)12684 M : 43 F50.5940 (31.5%)60 (47.2%)16 (21.6%)58 (78.4%)
+
(i.e., discrepant with histology)
158 M : 7 F59158 (53.3%)5 (33.3%)5 (45.5%)6 (54.5%)

Liposarcoma (definite/provisional)
(i.e., discrepant with histology)
155 M : 12 F6413.510 (66.7%)2 (13.3%)5 (38.5%)8 (61.5%)
+14292 M : 50 F6318113 (79.6%)27 (19.0%)31 (29.2%)75 (70.8%)