(a) |
| | | log2-fold change | | Muscle |
| Tumor over muscle | | | NRG1 | Neuregulin 1 | 9.909 | KSR2 | Kinase suppressor of ras 2 | 9.675 | MMP13 | Matrix metallopeptidase 13 (collagenase 3) | 9.528 | SPP1 | Secreted phosphoprotein 1 | 9.098 | INHBA | Inhibin, beta A | 8.570 | COL11A1 | Collagen, type XI, alpha 1 | 8.564 | MMP9 | Matrix metallopeptidase 9 (gelatinase B, 92 kda gelatinase, 92 kda type IV collagenase) | 8.552 | FBN2 | Fibrillin 2 | 8.495 | LRRC15 | Leucine rich repeat containing 15 | 8.429 | MMP11 | Matrix metallopeptidase 11 (stromelysin 3) | 8.336 | E2F7 | E2F transcription factor 7 | 8.314 | PRAME | Preferentially expressed antigen in melanoma | 8.179 | PTK7 | PTK7 protein tyrosine kinase 7 | 7.996 | DSCAM | Down syndrome cell adhesion molecule | 7.761 | RGS4 | Regulator of G-protein signaling 4 | 7.633 | CNIH3 | Cornichon homolog 3 (Drosophila) | 7.632 | OR10V1 | Olfactory receptor, family 10, subfamily V, member 1 | 7.610 | CEP55 | Centrosomal protein 55 kda | 7.583 | WNT5B | Wingless-type MMTV integration site family, member 5B | 7.569 | CA12 | Carbonic anhydrase XII | 7.520 | GALNT5 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) | 7.517 |
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(b) |
| | | log2-fold change | Bone |
| Tumor over bone | | | ROS1 | c-ros oncogene 1, receptor tyrosine kinase | 10.987 | GREM1 | Gremlin 1 | 10.604 | NPTX1 | Neuronal pentraxin I | 8.813 | GJB2 | Gap junction protein, beta 2, 26 kDa | 8.597 | CREB3L1 | cAMP responsive element binding protein 3-like 1 | 8.506 | KRT14 | Keratin 14 | 8.351 | SERPINE1 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 8.288 | HOXD10 | Homeobox D10 | 8.105 | ALPK2 | Alpha-Kinase 2 | 7.783 | POU3F2 | POU class 3 homeobox 2 | 7.530 | POSTN | Periostin, osteoblast specific factor | 7.497 | NAA11 | N(alpha)-acetyltransferase 11, NatA catalytic subunit | 7.439 | STC2 | Stanniocalcin 2 | 7.434 | WNT5A | Wingless-type MMTV integration site family, member 5A | 7.412 | IGFN1 | Immunoglobulin-like and fibronectin type III domain containing 1 | 7.387 | STC1 | Stanniocalcin 1 | 7.385 | FAM180A | Family with sequence similarity 180, member A | 7.315 | KRT17 | Keratin 17 | 7.305 | BBOX1 | Butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 7.277 | MAGEA1 | Melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | 7.267 |
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(c) |
| | | log2-fold change | | Muscle | Bone |
| Tumor over bone/muscle | | | | ANO4 | Anoctamin 4 (TMEM16D), transmembrane calcium-activated chloride channel, facilitates smooth muscle contraction | 9.937 | 8.542 | SLCO1B3 | (OATP1B3) Solute carrier organic anion transporter family, member 1B3 | 9.569 | 9.760 | MARCH4 | Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin ligase, located predominantly to the endoplasmic reticulum | 9.538 | 7.406 | IGF2BP1 | Insulin-like growth factor 2 mRNA binding protein 1 binds to and stabilizes mRNA | 9.440 | 9.631 | ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16; zinc-dependent protease | 9.260 | 8.450 | SOX11 | SRY (sex determining region Y)-box 11, important in brain development | 9.178 | 9.954 | HAPLN1 | Hyaluronan and proteoglycan link protein 1 stabilizes aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength and elasticity | 8.951 | 8.142 | MUC15 | Mucin 15, cell surface associated | 8.801 | 7.992 | HOXB9 | Homeobox B9 | 8.773 | 7.378 | MAGEC2 | Melanoma antigen family C, 2 | 8.693 | 8.884 | ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | 7.848 | 8.038 | C11orf41 | Chromosome 11 open reading frame 41 | 7.781 | 8.141 | MMP1 | Matrix metallopeptidase 1 (interstitial collagenase) | 7.455 | 7.646 |
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(d) |
| Symbol | Name | log2-fold change | log2-fold change | Muscle | Bone |
| Tumor over bone/muscle | | | | | | FN1 | Fibronectin 1 | 7.328 | 6.293 | 6.457 | 19.860 | COL1A1 | Collagen, type I, alpha 1 | 6.768 | 3.706 | 5.868 | 11.934 | CCND1 | Cyclin D1 | 5.595 | 3.958 | 5.098 | 9.637 | RGS1 | Regulator of G-protein signaling 1 | 5.118 | 1.056 | 4.653 | 2.533 | ITGBL1 | Integrin, beta-like 1 (with EGF-like repeat domains) | 5.071 | 3.177 | 3.895 | 12.415 | COL1A2 | Collagen, type I, alpha 2 | 4.852 | 8.756 | 4.910 | 14.503 | MXRA5 | Matrix-remodelling associated 5 | 4.834 | 1.352 | 4.631 | 2.685 | POSTN | Periostin, osteoblast specific factor | 4.513 | 5.870 | 7.497 | 1.267 | PLOD2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 4.285 | 1.801 | 4.023 | 3.730 | COL5A2 | Collagen, type V, alpha 2 | 4.275 | 1.297 | 4.833 | 1.517 | COL3A1 | Collagen, type III, alpha 1 | 4.003 | 13.118 | 5.801 | 6.500 | SEMA3C | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted | 3.954 | 1.164 | 4.215 | 1.675 | FBN1 | Fibrillin 1 | 3.912 | 6.957 | 4.018 | 11.148 | AEBP1 | AE binding protein 1 | 3.808 | 3.212 | 4.002 | 4.843 | SIK1 | Salt-inducible kinase 1 | 3.805 | 1.219 | 3.566 | 2.484 | SERPINH1 | Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1 | 3.706 | 1.652 | 4.145 | 2.098 | ANTXR1 | Anthrax toxin receptor 1 | 3.670 | 3.789 | 3.690 | 6.445 |
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(e) |
| Symbol | Name | log2-fold change | log2-fold change | Muscle | Bone |
| HELLS | Helicase, lymphoid-specific | 5.315602 | 0.155898 | −0.82713 | 20.2489 | TNFRSF11A | Tumor necrosis factor receptor superfamily, member 11a, and NFKB activator | 3.017922 | 0.03091 | 1.400993 | 0.202453 | NFKBID | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta | 2.655352 | 0 | −1.47615 | 0.504341 | TNFRSF25 | Tumor necrosis factor receptor superfamily, member 25 | 2.432959 | 0.046388 | 0.163954 | 0.490795 | NFKBIE | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 2.121015 | 0.062395 | 0.311441 | 0.43382 | TNF | Tumor necrosis factor | 1.847997 | 0 | −1.42101 | 0.03733 | TNFRSF10D | Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 1.754888 | 0.172968 | −0.1757 | 1.183343 | TNFRSF1B | Tumor necrosis factor receptor superfamily, member 1B | 1.473438 | 0.709902 | −0.97011 | 6.729401 | TNFRSF10A | Tumor necrosis factor receptor superfamily, member 10a | 1.411898 | 0.828219 | 0.357701 | 3.004386 | NFKBIB | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 1.193993 | 1.209816 | 0.46055 | 3.484692 | TNFRSF10B | Tumor necrosis factor receptor superfamily, member 10b | 1.094157 | 1.908597 | 0.425446 | 5.242006 | TNFRSF21 | Tumor necrosis factor receptor superfamily, member 21 | 1.055762 | 3.882038 | 0.745815 | 8.305711 | TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | 0.875167 | 3.790938 | −0.11707 | 13.0344 | NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.575974 | 3.698951 | 0.344657 | 7.493136 | RIPK1 | Receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.494467 | 3.11749 | −1.08854 | 16.1392 | NKRF | NFKB repressing factor | 0.475722 | 2.156087 | −0.86397 | 9.434166 | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.432959 | 2.054532 | −0.65865 | 7.568586 | CHUK | Conserved helix-loop-helix ubiquitous kinase | 0.176126 | 2.961281 | −1.20204 | 13.30333 | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.013848 | 1.263837 | 0.287167 | 1.803044 | NFKB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | −0.08641 | 0.312993 | 0.485882 | 0.360442 | NKAPP1 | NFKB activating protein pseudogene 1 | −0.10692 | 0.825177 | −0.99449 | 2.655392 | TNFRSF10C | Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | −0.152 | 0.064676 | −5.56891 | 6.321515 | NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | −0.60768 | 1.095135 | −0.88758 | 2.299946 | NFKBIL1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | −0.8719 | 0.141933 | −0.08357 | 0.140418 | NKIRAS1 | NFKB inhibitor interacting Ras-like 1 | −0.87428 | 6.296399 | 1.467735 | 2.122983 | TANK | TRAF family member-associated NFKB activator | −0.983 | 6.777124 | −1.51908 | 16.95872 | NKAP | NFKB activating protein | −1.35735 | 14.22458 | −0.78243 | 16.46287 | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | −1.85483 | 40.32743 | −0.31802 | 23.95275 | NKAPL | NFKB activating protein-like | −5.57347 | 5.875743 | −1.40215 | 0.534643 |
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