Sarcoma

Research Article

HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS

Table 1

Patient clinical history.


Patient	Age¹	Major comorbidities²	KS location	Time since KS diagnosis (months)	Length of HIV infection (years)	Anatomical location of biopsy	Concentration (ng/μL)		Number of env sequences		Number of nef sequences
Patient	Age¹	Major comorbidities²	KS location	Time since KS diagnosis (months)	Length of HIV infection (years)	Anatomical location of biopsy	RNA	DNA	RNA	DNA	RNA	DNA

KS1	34	Lymphoma, MAC, PCP, cytomegalovirus	Skin, pleura, lungs, trachea, lymph node, liver, adrenal glands	Unknown	7	KS skin	144	154	22	8	24	9
						KS lymph node	168	276	13	21	14	21
						Lymph node	120	12.1	37	22	35	26
						Kidney	>200	8.18	5	0	9	0

KS2	31	BCBL	Skin, pleura, lungs, esophagus, small bowel	~5	Unknown	KS skin	165	44	14	10	18	12
						KS small bowel	192	9.84	4	0	5	0
						Liver	191	8.42	0	0	0	0
						Spleen	190	13.9	23	1	31	2

KS3	28	Aggressive KS	Skin, pleura, lungs, trachea, esophagus, small bowel, colon, rectum, iliac lymph nodes, mesenteric lymph nodes, para-aortic lymph nodes, paratracheal lymph nodes	~1	9	KS skin	49	51	6	2	2	6
						KS small bowel	164	39.4	16	25	14	24
						Liver	161	33.4	14	5	15	5
						Stomach	78.2	40.2	24	8	20	8

Age in years; ²MAC: Mycobacterium avium complex; PCP: Pneumocystis pneumonia; BCBL: body cavity based lymphoma.