| Number | Nr with genetic confirmation (any method) | Reference | Pub year | Age at Dx PT | Age at Dx ES | Latency (y) | Primary cancer | Location ES | Molecular test | Treatment of the primary hematological malignancy | Anthracyclines, TopoII-INH | Vinca | Alkylating agent | Antimetabolite | Other drugs | Rth | Additional treatment |
| 1 | | Meadows et al. [27] | 1977 | | | 5 | ALL | ND | ND | | | | | | | | 2 | 1 | Tilly et al. [26] | 1984 | 8 | 19 | 11 | ALL | Sacrum | Karyotype | DNR | VCR | DTIC | | PD | Cranial RT 24 Gy | | 3 | | Anselmo et al. [34] | 1994 | 20 | 27 | 7 | HL | Chest wall | ND | | | | | | | | 4 | 2 | Zoubek et al. [28] | 1995 | 12 | 20 | 8 | Anaplastic T LCL | Pelvis | Karyotype RT-PCR | VP16 | | CPA, MEL | MTX, Ara-C | | TBI 12 Gy | SCT (auto) | 5 | | Delgado-Chavez et al. [35] | 1995 | 22 | 26 | 4 | HL | Chest wall | ND | | | | | | | | 6 | 3 | Antillon et al. [29] | 1997 | 7 | 16 | 9 | ALL | Tibia | RT-PCR | DNR | VCR | | | PD, L-asp | | | 7 | | Aparicio et al. [30] | 1998 | 3 | 15 | 12 | ALL | Ulna | ND | ADR | VCR | | 6-MP, MTX, Ara-C | L-asp | Cranial RT | | 8 | | 11 | 18 | 7 | AML | Fibula | ND | DNR, ADR, MTZ, VP16 | | | 6-MP, 6-TG, Ara-C | | | | 9 | | Bisogno et al. [31] | 2004 | 4 | 7 | 3 | HL | Thoracic wall | ND | ADR | VBL | DTIC | | | RT 20 Gy | | 10 | | 7 | 18 | 11 | CML | Thigh | ND | | | | HU | | TBI 9 Gy, | SCT (allo) | 11 | | Suarez et al. [36] | 2004 | 8 | 9 | 1 | ALL | Chest wall | ND | ARD | VCR | CPA | MTX, 6-MP, Ara-C | PD | | | 12 | 4 | Kim et al. [32] | 2005 | 3 | 7 | 4 | ALL | Humerus | Karyotype RT-PCR | ADR | VCR | CPA | 6-TG, MTX, Ara-C | PD, L-asp | | | 13 | 5 | Spunt et al. [33] | 2006 | 9 | 12 | 3 | LCL | Rib | FISH | ADR | VCR | CPA | | PD | RT 15 Gy | | 14 | 6 | 8 | 16 | 8 | ALL | Tibia | RT-PCR | DNR, VP16 | VCR | CPA | 6-MP, MTX, Ara-C | PD, L-asp | | | 15 | 7 | 7 | 23 | 16 | Small, noncleaved cell lymphoma | Rib | FISH | ADR | VCR | CPA | MTX, Ara-C | | | | 16 | 8 | 12 | 17 | 5 | HL | Chest wall | RT-PCR | ADR, BLE | VBL | | MTX | PD | | | 17 | | Khadwal et al. [37] | 2006 | 8 | 10 | 2 | HL | Knee | ND | ADR, BLE | VBL | | | | RT 24 Gy | | 18 | 9 | Osone et al. [38] | 2007 | 10 | 16 | 6 | ALL | Urinary bladder | RT-PCR | ADR | VCR | CPA | MTX, 6-TG | PD, L-asp | none | | 19 | | Renard et al. [39] | 2011 | 7 | 19 | 12 | ALL | ND | ND | ND | ND | ND | ND | ND | ND | ND | 20 | 10 | Lim et al. [40] | 2013 | 20 | 22 | 2 | Burkitt | Adrenal gland | FISH | ADR | VCR | CPA | MTX, Ara-C | DEXA | | | 21 | 11 | Hiramoto et al. [14] | 2013 | 57 | 65 | 8 | B-LCL | Soft tissue back | RT-PCR | DNR | VCR | CPA | | PD | | GCSF | 14 more cases | | Applebaum et al. [25] | 2013 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | 36 | 12 | Current series | 2016 | 5 | 8 | 3 | Lymphoblastic lymphoma | Paravertebral | RT-PCR | ADR | | CPA, IFO | Ara-C | | | | 37 | 13 | Current series | 2016 | 16 | 21 | 4 | T-ALL | Brain | FISH | DNR | VCR | CPA | MTX, Ara-C, 6-MP, 6-TG | | RT 12 Gy | | 38 | 14 | Current series | 2016 | 9 | 11 | 2 | T-ALL | Mandible | FISH, RT-PCR | DNR | VCR | CPA | MTX, Ara-C, 6-MP | | TBI RT 12 Gy | |
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DNR, daunorubicin; VP-16, etoposide; ADR, doxorubicin; ACT, actinomycin D; MTZ, mitoxantrone; BLE, bleomycin; VCR, vincristine; VBL, vinblastine; DTIC, dacarbazine; CPA, cyclophosphamide; MEL, melphalan; IFO, ifosfamide; MTX, methotrexate; Ara-C, cytarabine; 6-MP, 6-mercaptopurine; 6-TG, thioguanine; HU, hydroxyurea; PD, prednisone; L-asp, L-asparaginase; RT, radiotherapy; TBI, total body irradiation; SCT, stem cell transplantation. ND: no data.
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