How Effective Are Noninvasive Tests for Diagnosing Malignant Peripheral Nerve Sheath Tumors in Patients with Neurofibromatosis Type 1? Diagnosing MPNST in NF1 Patients
Table 2
Sensitivity, specificity, positive predictive values, and negative predictive values, along with their associated confidence intervals, for potential predictors of malignancy. These included tumor characteristics (depth relative to the fascia, and size > 5 cm in diameter), MRI findings (any necrosis, or necrosis >25% by volume), PET findings (SUVmax > 5, SUV peak > 4.5, and TLR > 3), and clinical findings (pain, enlarging, and nerve symptoms). Combinations of imaging findings (SUVpeak > or < 4.5 on PET and any or >25% necrosis on MRI) and clinical findings (1 of 3, 2 of 3, or 3 of 3 symptoms) are also included.