Research Article
Establishment of an Academic Tissue Microarray Platform as a Tool for Soft Tissue Sarcoma Research
Table 2
Special subtype-specific tissue microarrays for (longitudinal) tumor biology studies.
| Name of tissue microarrays | Soft tissue sarcoma subtypes | Different stages of samples in pairs | Number of cases |
| UZL_TMA_CCSA | Clear cell sarcoma | Primary tumor, metastatic lesion, and/or local recurrence | 5 | UZL_TMA_ASPS | Alveolar soft part sarcoma | Primary tumor and metastatic lesions | 2 | UZL_TMA_ARMS | Alveolar rhabdomyosarcoma | Primary tumor, metastatic lesion, and/or local recurrence | 4 | UZL_TMA_LMS | Leiomyosarcoma | Primary tumor, metastatic lesion, and/or local recurrence | 36 |
| | | Different types of mutations | | UZL_TMA_GIST | Gastrointestinal stromal tumor | KIT exon 9 | 9 | KIT exon 11 deletion including codons 557/558 | 10 | KIT exon 11 substitutions | 9 | KIT exon 11 duplication | 7 | KIT exon 11 deletion outside codons 557/558 | 5 | KIT exon 11 + 17 | 5 | KIT exon 11 + 13 | 4 | KIT exon 11 p. W557_K558 deletion on codon 557–558 | 4 | PDGFRA p. D842 V | 7 | PDGFRA other exon 18 mutation | 5 | No KIT/PDGFRA mutation | 7 | | | Different subgroups of LPS | | UZL_TMA_LPS | Liposarcoma | Well differentiated | 14 | Dedifferentiated | 11 | Myxoid/round cell | 10 | Pleomorphic | 6 |
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PDGFR-A: platelet-derived growth factor receptor-alpha.
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