Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation
Table 3
The semantic decision match fmri task: neuroimaging results: 3D cluster sizes, talairach coordinates (of peak voxels) and cluster values for main effects of the semantic congruency.
(a) Within group analysis: congruent versus incongruent trials in healthy controls (). Displayed only clusters > or = 6 in size
Contrast
Size
Tal()
Tal()
Tal()
Probability
Cerebral region
Congruent > Incongruent
2189
43.33
14.81
14.85
0.000656
Left inferior frontal gyrus, dorsal portion
312
46.94
29.63
−7.15
0.000656
Right inferior frontal gyrus, orbital portion
181
0.00
11.11
31.35
0.000656
Bilateral anterior cingulate gyrus
3
14.44
11.11
25.85
0.008530
Right anterior cingulate gyrus
15
10.83
22.22
−1.65
0.000656
Right caudate
7
−36.11
−48.15
3.85
0.001969
Left middle temporal gyrus
6
−21.67
−29.63
−12.65
0.001969
Left parahippocampal gyrus
6
21.67
−66.67
36.85
0.004593
Right precuneus
Incongruent > Congruent
3094
−32.50
37.04
25.85
0.000678
Left middle frontal gyrus
15
3.61
44.44
25.85
0.004749
Right medial frontal gyrus
14
−21.67
55.56
9.35
0.000678
Left superior frontal gyrus
(b) Between Groups Analyses:. 3-Group ANOVA: Semantic Congruency (congruent versus incongruent) trials. Comparison of healthy controls () versus schizophrenic patients with Formal Thought Disorder (FTD, ) versus schizophrenic patients without formal thought disorder (Non-FTD, )
Results
Size
Tal()
Tal()
Tal()
Probability
Cerebral Region
Controls > NTD > TD
79
−43.33
14.81
14.85
0.007784
Left inferior frontal gyrus, dorsal portion
(c) Post-hoc 2 group comparisons: semantic congruency (congruent versus incongruent trials) schizophrenic patients with formal thought disorder (FTD, ) versus healthy controls () and FTD versus schizophrenic patients without formal thought disorder (Non-FTD, )
