Stem Cells International / 2010 / Article / Tab 2 / Review Article
Phases I–III Clinical Trials Using Adult Stem Cells Table 2 Randomized clinical trials with granulocyte colony-stimulating factor in patients with acute myocardial infarction (subcutaneous).
Trial (year) n Dose Timing after AMI (PCI) Followup Comments Valgimigli [28 ] (2005) 20 5 μ g/kg × 4 d 1 d No change LVEF at 6 m LVEF by SPECT FIRSTLINE-AMI [16 ] (2005) 50 10 μ g/kg × 6 d 90 min Improved LVEF at 4 m LVEF by echocardiography REVIVAL-2 [29 ] (2006) 114 10 μ g/kg × 5 d 5 d No change LVEF at 5 m LVEF by MRI STEMMI [30 ] (2006) 78 10 μ g/kg × 6 d 28 h No change LVEF at 6 m LVEF by echocardiography and MRI G-CSF-STEMI [31 ] (2006) 44 10 μ g/kg × 5 d 35 h No change LVEF at 3 m LVEF by MRI Ellis [32 ] (2006) 18 5 μ g/kg × 5 d (low d), 10 μ g/kg × 5 d (high d) < 30 hImproved LVEF at 30 d LVEF by echocardiography RIGENERA [17 ] (2007) 41 10 μ g/kg × 5 d 5 d Improved LVEF at 6 m LVEF by echocardiography Takano [18 ] (2007) 40 2,5 μ g/kg × 5 d 1 d Improved LVEF at 6 m LVEF by SPECT MAGIC [19 ] (2004)* 27 10 μ g/kg × 4 d; PBC: 1 × 109 1 d No change LVEF at 6 m LVEF by SPECT MAGIC 3-DES [20 ] (2006)* 50 10 μ g/kg × 3 d; PBC: 2 × 109 1 d Improved LVEF at 6 m LVEF by MRI
*MAGIC trials used a combination of indirect mobilization (G-CSF) and direct intracoronary injection of peripheral blood cells (PBC); LVEF: left ventricular ejection fraction; SPECT: single-photon emission computed tomography; MRI: magnetic resonance imaging.