Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss
Figure 2
hMNP differentiation in vivo. Human nuclear (Ku80) antigen-positive cells were detected in all treated animals of all 3 animal models and colabeled with different motor neuron differentiation markers. Human nuclear (Ku80) antigen-positive cells (a, c) double stained with Islet-1 ((b) red), NeuN ((d) NeuN in red, human nuclei in green), p75 ((e) p75 in red, human nuclei in green), or ChAT ((f) ChAT in blue, human nuclei in brown), consistent with a motor neuron lineage of mixed maturation state. Bar = 50 μm.
