Table 3: Protein precursors abundant in UCBS and their possible functions in in vitro MSC-culture.

S. no.Protein precursorIn Vitro effects on hMSCs

(1)Alpha-2-macroglobulin precursor(i) Natural protease inhibitor
(ii) Role in cell regulation and differentiation

(2)Apolipoprotein B-100 precursor(i) Cholesterol transporter activity,

(3)Complement C3 precursor(i) Positive regulation of VEGF production
(ii) G-protein coupled receptor protein signaling pathway
(iii) Natural protease inhibitor

(4)Complement C5 precursor(i) Chemotaxis, positive regulation of VEGF production
(ii) Natural protease inhibitor
(iii) G-protein coupled receptor protein signaling pathway
(iv) Positive regulation of chemokine production

(5)Isoform 1 of complement factor H precursor(i) Negative regulation of complement C3