Review Article

Proteomic Definitions of Mesenchymal Stem Cells

Figure 2

Expression of cell surface markers of MSCs. Hierarchical clustering of the expression of cell surface markers of MSCs from different MSCs preparations. Cells were termed “mesenchymal stem cells (MSCs)" [11], “mesodermal progenitor cells (MPCs)" [12], “marrow-isolated adult multilineage inducible (MIAMI) cells" [13], and “bone marrow-isolated mesenchymal stem cells (BM-MSCs)," “adipose tissue-isolated stem cells (ADSCs)," “synovia-derived stem cells (SynoSCs)," “umbilical vein stem cells (UVSCs)," and “human embryonic stem cells (hESCs)" [14]. The figure shows the different cell preparations in columns and the surface antigens in rows. The green color codes for positive expression, yellow codes for low expression, red codes for no expression, and grey color stands for not determined in the respective experiments. It is seen that the cells can be defined by the presence and absence of a distinct pattern of cell surface markers, that is, CD34(−), CD45(−), CD117(−) (cKit), CD44(+), CD90(+), and CD166(+).
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