Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats

Figure 6

HuUCBMCs grafts modulate glial reactivity in 3-AP ataxic rats. (a), (b), and (c) show GLUT5 (a), OX6 (b), and GFAP (c) protein levels in the cerebellum and brain stem of 3-AP-lesioned rats receiving vehicle (3-AP + vehicle rats, white bars) or HuUCBMCs grafts (3-AP + cells rats, black bars). Note how HuUCBMCs transplantation upregulates OX6 protein expression in the brain stem and reduces GFAP protein levels in the cerebellum of 3-AP-lesioned rats. (a1) and (a2) show representative blots for GLUT5, (b1) and (b2) for OX6, and (c1) and (c2) for GFAP in the cerebellum (a1, b1, and c1) and brain stem (a2, b2, and c2). Lane 1: naïve rats (control); lane 2: 3-AP + vehicle; lane 3: 3-AP + cells. Results represent the mean ± SEM of 9 to 15 individual animals. ^∗𝑃≤0.05, ^∗∗𝑃≤0.01 versus naïve rats, ⁺𝑃≤0.05 versus 3-AP + vehicle rats.