The Influence of Brightness on Functional Assessment by mfERG: A Study on Scaffolds Used in Retinal Cell Transplantation in Pigs

<table>Mean values of white and blue membranes and correlation between brightness ratio (membrane/optic disc) and P1-amplitude ratio (left/right). Large symbols represent mean ± SEM for white and blue membranes and show a significant difference in P1-amplitude ratio (<svg height="11.375" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 78.199997 11.375" width="78.199997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.26,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,41.624,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.784,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.66,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.819,11.112)"><use xlink:href="#x32"></use></g><g transform="matrix(.017,-0,0,-.017,69.978,11.112)"><use xlink:href="#x37"></use></g>
</svg>) and brightness ratio (<svg height="11.375" id="M12" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 78.199997 11.375" width="78.199997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.26,11.112)"><path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path></g><g transform="matrix(.017,-0,0,-.017,41.624,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.784,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.66,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.819,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,69.978,11.112)"><path d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" id="x31"></path></g>
</svg>). When observed together, the blue (●) and white (°) membranes show a significant correlation (<svg height="11.225" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 68.900002 11.225" width="68.900002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.963)"><path d="M393 379q-9 -16 -28 -29q-15 -10 -23 -2q-19 19 -36 19q-21 0 -52 -38q-57 -72 -82 -126l-40 -197q-23 -3 -75 -18l-7 7q49 196 74 335q7 43 -2 43q-7 0 -30 -14.5t-47 -37.5l-16 23q37 42 82 73t67 31q41 0 15 -113l-11 -50h4q41 71 85 117t77 46q29 0 45 -26
q13 -21 0 -43z" id="x1D45F"></path></g><g transform="matrix(.017,-0,0,-.017,11.945,10.963)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,26.649,10.963)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,34.808,10.963)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,44.344,10.963)"><use xlink:href="#x37"></use></g><g transform="matrix(.017,-0,0,-.017,52.504,10.963)"><path d="M137 343l67 33q37 17 63 17q79 0 129.5 -53t50.5 -131q0 -92 -58 -156.5t-147 -64.5t-147 68t-58 182q0 63 17 119t43 95.5t61.5 72t69 52t67.5 31.5q62 22 128 33l6 -32q-56 -11 -108 -35q-149 -71 -184 -231zM227 337q-47 0 -95 -27q-6 -23 -6 -70q0 -93 36 -155.5
t96 -62.5q53 0 78 45.5t25 105.5q0 68 -35 116t-99 48z" id="x36"></path></g><g transform="matrix(.017,-0,0,-.017,60.663,10.963)"><use xlink:href="#x32"></use></g>
</svg>;  <svg height="11.375" id="M14" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 78.199997 11.375" width="78.199997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.26,11.112)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,41.624,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.784,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.66,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.819,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,69.978,11.112)"><use xlink:href="#x36"></use></g>
</svg>).</table>

Stem Cells International

fig5

Figure 5

Figure 5: The Influence of Brightness on Functional Assessment by mfERG: A Study on Scaffolds Used in Retinal Cell Transplantation in Pigs 