The Potential of Stem Cells in the Treatment of Skeletal Muscle Injury and Disease

Table 1

Potential of other cell sources for skeletal muscle engineering.

Cell type	Source	Potential advantages
Skeletal muscle side population	Skeletal muscle	Can be delivered systemically; May have increased capacity to incorporate into stem cell of muscle
Muscle-derived stem cells	Skeletal muscle	Can undergo myogenic and osteogenic differentiation Can repopulate haematopoietic lineage
Mesoangioblasts	Other mesodermal tissues, for example, dorsal aorta	Can be delivered systemically; May be able to efficiently regenerate normal skeletal muscle
Pericytes	Basement membrane adjacent to endothelial cells; Pancreas, adipose tissue, placenta	May improve the physiological performance of skeletal muscle; Can be easily manipulated in vitro to reduce host’s immune response
Adipocytes	Adipose tissue	Proven good differentiation into myogenic cells in vitro and in vivo
Embryonic stem cells and induced-pluripotent stem cells		Can regenerate acutely and chronically injured muscle but concerns of tumourigenic potential and ethical concerns