Stem Cell Niche Dynamics: From Homeostasis to Carcinogenesis
Figure 2
Structural and dynamic aspects of the Drosophila intestinal stem cell (ISC) niche. The left panel shows a structural picture of the Drosophila intestine, while the right panel reveals population and regulatory elements of a mathematical model for ISC regulation. Populations of the intestinal stem cell niche in the Drosophila include ISCs, enteroblasts (EBs), enteroendocrine cells (EE), and enterocytes (ECs). Wnt signaling from underlying smooth muscle and Notch feedback from EB regulate ISC self-renewal, while Jak/Stat feedback from damaged ECs increases ISC self-renewal.
