Cellular Programming and Reprogramming: Sculpting Cell Fate for the Production of Dopamine Neurons for Cell Therapy

<table>During embryogenesis ventral midbrain dopamine neurons are born at the intersection of three signaling molecules, Shh, Wnt1 and Fgf8, that pattern the neural tube along rostrocaudal, dorsoventral and mediolateral axes. Sagittal and coronal views at the midbrain and spinal cord levels of the mouse embryo showing the expression patterns of these morphogens at E9.5. <b>FP</b>: floor plate; IsO: isthmic organizer; MB: midbrain; NC: notochord; OV: otic vesicle; <b>RP</b>: roof plate; SC: spinal cord; ZLI: zona limitans intermedia.</table>

Stem Cells International

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Figure 2: Cellular Programming and Reprogramming: Sculpting Cell Fate for the Production of Dopamine Neurons for Cell Therapy 