The Promise of Human Induced Pluripotent Stem Cells in Dental Research

Table 1

Disease-specific-induced pluripotent stem cells (iPSCs) lines from various human genetic disorders.

Disease category	Disease	References
Neural	Amyotrophic lateral sclerosis	[31]
	Parkinson’s disease	[11, 22, 33, 34]
	Huntington’s disease	[11, 35]
	Lesch-Nyhan syndrome	[11]
	Rett syndrome	[36]
	Familial dysautonomia	[37]
	Angelman syndrome	[38]
	Prader-Willi syndrome	[38, 39]
	Friedreich’s ataxia	[40]
	Rett syndrome	[41]
	Schizophrenia	[42]
Immune system	ADA-SCID	[11]
	Scleroderma	[43]
	Primary immunodeficiency	[44]
Muscular	Duchenne muscular dystrophy	[11]
	Becker muscular dystrophy	[11]
	Spinal muscular atrophy	[25]
	Duchenne muscular dystrophy	[45]
Blood	Thalassemia	[46, 47]
	Sickle cell anemia	[43, 47]
	Chronic myeloid leukemia	[48]
Heart	Long QT syndrome	[49, 50]
Pancreas	Juvenile diabetes mellitus	[11]
	Shwachman-Bodian-Diamond syndrome	[11]
	Type I diabetes	[51]
Skin	Leopard syndrome	[52]
	Recessive dystrophic, Epidermolysis bullosa	[53]
Bone marrow	Fanconi anemia	[54]
	Myeloproliferative diseases	[54]
Liver	Liver diseases: a1-antitrypsin deficiency, familial hypercholesterolemia, glycogen storagedisease type 1a, Crigler-Najjar, tyrosinemia type 1	[55]
Lung	Lung diseases: cystic fibrosis, a-1 antitrypsin deficiency-related emphysema	[43]
Others (physical and intellectual limitations)	Down syndrome	[11]
	Hurler syndrome	[44]
	Gaucher disease	[11]
	Fragile X syndrome	[56]
Premature ageing	Dyskeratosis congenital	[57]
Eye	Retinitis pigmentosa	[58]
	gyrate atrophy	[59]
Dental	?