Early Growth Response Genes Signaling Supports Strong Paracrine Capability of Mesenchymal Stem Cells

Figure 1

The roles of EGR1 and EGR2 signaling and autocrine loops with EGFR and PDGFR ligands in the production of select bioactive molecules in MSCs. (Abbreviations: CTGF, connective tissue growth factor; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; EGR, early growth response gene; HBEGF, heparin-binding epidermal growth factor-like growth factor; IDO1, indoleamine dioxygenase-1; IL1B, interleukin-1beta; IL6, interleukin-6; LIF, leukemia inhibitory factor; PDGFA, platelet-derived growth factor-A; PDGFB, platelet-derived growth factor-B; PTGS2/cox2, prostaglandin-endoperoxide synthase 2/cyclooxygenase-2; TGFB1, transforming growth factor-beta1; VEGFA, vascular endothelial growth factor-A).