Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation

Table 2

Details in regards to dogs in the masked ERG study. The genotypes are given as −/− for genetically affected, +/− for carriers, and +/+ for genetically clear individuals of the 44 bp deletion in exon 2 of the RPGRIP1 gene. The age at the time for ophthalmic and ERG examinations is given as years (y) and months (m).

Dog number	RPGRIP1 genotype	Age at ERG	ERG results	Other clinical findings
1	−/−	9 y 2 m	Abnormal	Normal vision, fundus normal
2	+/−	8 y 7 m	Normal	Normal vision, fundus normal
3	+/−	7 y 9 m	Normal	Normal vision, fundus normal
4	+/−	7 y 9 m	Normal	Normal vision, fundus normal
5	+/−	13 y 10 m	Normal	Normal vision, fundus normal
6	+/−	11 y 11 m	Normal	Normal vision, fundus normal
7	−/−	9 y 2 m	Abnormal	Normal vision, fundus abnormal
8	−/−	9 y 2 m	Abnormal	Normal vision, fundus abnormal
9	−/−	8 y 4 m	Normal	Normal vision, fundus normal
10	+/−	9 y 4 m	Normal	Normal vision, fundus normal
11	+/−	8 y	Normal	Normal vision, fundus normal
12	+/+	9 y 3 m	Normal	Normal vision, fundus normal
13	−/−	12 y 4 m	Abnormal	Reduced vision, fundus abnormal
14	−/−	7 y	Normal	Normal vision, fundus normal