|
AF cell source | Target tissue | Animal/disease model | Delivery route | References |
|
Human | Brain | Normal and twitcher neonatal mice | Intracerebroventricular injection | [14] |
Human | Brain | Mouse cerebral ischemia | Intracerebroventricular injection | [109] |
Human | Brain | Rat cerebral ischemia | Intrastriatal injection | [110] |
Rat | Brain | Rat cerebral ischemia | Intravenous injection into the jugular vein | [111] |
Human | Brain | Mouse motor cortex injury | Injection or implantation of cells seeded on biocompatible scaffolds into the motor cortex | [112] |
Human | Nerve | Rat sciatic nerve crush injury | Injection or implantation of cells and fibrin glue into the injury site | [113ā117] |
Human | Nerve, Muscle | Rat sciatic nerve crush injury | Intravenous injection | [118] |
Human | Heart | Rat cardiac infarction | Intracardiac injection of cells or cell sheet fragments | [119, 120] |
Rat | Heart | Rat cardiac infarction | Intracardiac injection | [108, 121, 122] |
Human | Lung, Heart | Rat pulmonary hypertension and heart failure | Intravenous injection into the tail vein | [123] |
Sheep | Heart valve | Fetal sheep | Closed-heart implantation of cells seeded on biodegradable scaffolds in utero | [104] |
Mouse | Skeletal muscle | Mouse spinal muscular atrophy | Intravenous injection into the tail vein | [124] |
Human | Bone | Mouse subcutaneous implantation | Subcutaneous implantation of cells printed on biocompatible polymers | [14] |
Rabbit | Bone | Rabbit chest wall/sternal defects | Bone graft implantation of cells seeded on biocompatible scaffolds into the injury site | [99] |
Human | Bone | Rat subcutaneous implantation | Subcutaneous implantation of cells seeded on biocompatible polymers | [101] |
Sheep | Cartilage | Fetal lamb tracheal reconstruction | Tracheal implantation of cells seeded on biocompatible scaffolds in utero | [96] |
Sheep | Diaphragm | Postnatal sheep diaphragmatic hernia | Diaphragmatic implantation of cells seeded on biocompatible scaffolds | [97] |
Human | Kidney | Mouse kidney acute tubular necrosis | Injection into the renal cortex | [106] |
Rat | Bladder | Rat cryo-injured bladder | Intravascular injection | [105] |
Rat | Abdomen | Rat | Intraperitoneal injection | [125] |
Rabbit | Fetal membranes | Fetal rabbit iatrogenic membrane defect | Injection into the plug followed by fixation to the fetal membranes | [126] |
Sheep | Nonspecific | Fetal lamb organs | Injection into the fetal peritoneal cavity in utero | [127] |
Mouse, Human | Hematopoietic | Mouse | Intravenous injection into the retro-orbital vein | [128] |
|