|
Reference | Model (animal/injury/level) | Factor | | Graft | Histological effect | Functional effect |
|
Grill et al., [78] | Rat/dorsal hemisection and dorsal column lesion/T7 | NT3 | 21 | Fibroblast | Corticospinal axon growth | Locomotor score improvement |
|
Houweling et al., [66] | Rat/partial transection/T9 | BDNF | 9 |
NA | None | Locomotor score improvement within 1 week of injury; none at later f/u |
|
McTigue et al., [67] | Rat/contusion/T8 | NT3 | 6 | Fibroblast | Cell growth into graft, remyelination | NA |
BDNF | 12 | Fibroblast | Cell growth into graft, remyelination | NA |
bFGF | 5 | Fibroblast | None | NA |
NGF | 5 | Fibroblast | None | NA |
|
Lee et al., [73] | Rat/contusion/T10 | bFGF | 5 | NA | Reduction in necrosis | NA |
NGF | 5 | NA | None | NA |
|
Liu et al., [68] | Rat/partial hemisection/C3 | BDNF | 72 | Fibroblast | Rubrospinal axon regeneration | Partial recovery of forelimb function |
|
Rabchevsky et al., [76] | Rat/contusion/T10 | bFGF | 18 | NA | Reduction in necrosis | Partial recovery of motor function at all f/u (up to 6 weeks) |
|
Namiki et al., [69] | Rat/compression/T3 | BDNF | 6 | NA | None
| Higher inclined plane score 1 week following injury; none at later f/u |
NGF | 6 | NA | None | None |
NT3 | 6 | NA | None | None |
|
Rabchevsky et al., [77] | Rat/contusion/T10 | bFGF | 16 | NA | None | Partial recovery of motor function at all f/u (up to 6 weeks) |
|
Tuszynski et al., 2002 | Rat/dorsal hemisection /T7 | NT3 | 66 | Fibroblast | Corticospinal axon growth | Locomotor score improvement |
|
Blesch and Tuszynski, [4] | Rat/complete transection and dorsal hemisection/T7 | GDNF | 44 | Fibroblast | Cell growth into graft, remyelination | None at 4 weeks (first f/u) and beyond. |
|
Brock et al., [70] | Primate/lateral hemisection/C7 | BDNF & NT3 | 7 | Fibroblast | Neural growth into graft, neuroprotection of corticospinal neurons | NA |
|