Review Article
Regulation of Injury-Induced Neurogenesis by Nitric Oxide
Table 3
NO-dependent signal pathways in neurogenesis.
| | NO source | Effect | Signaling pathway | References |
| | nNOS | proliferation (SVZ) | Nitrosylation of EGF receptor | [127] | | (PI3-K)/Akt pathway | [107, 127] | | neurogenesis (DG) | PSA-NCAM and CREB | [134] | | cAMP phosphorylation | [113] | | eNOS | neurogenesis (DG and SVZ) | BDNF and VEGF | [135] | | neurogenesis (DG) | VEGF | [128] | | iNOS | proliferation (SVZ) | ERK 1/2 pathway | [74] | | cGMP/PKG pathway | [115] | | migration (NT2 cell line) | cGMP/PKG pathway | [136] | | neurogenesis (DG) | NMDA receptor | [130, 137] | | neurogenesis (DG and SVZ) | L-VGCC | [138] | | astrogliogenesis | JAK/STAT-1 pathway | [112] |
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: Increase; : decrease; Brain-derived neurotrophic factor, BDNF; Vascular endothelial growth factor, VEGF; L-type voltage-gated Ca2+ channel, L-VGCC.
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