Expression of SIRT1 and DBC1 in Developing and Adult Retinas
Figure 1
Expression of SIRT1 and DBC1 in fetal and adult human eyes. SIRT1 was exclusively cytoplasmic in the retinas of all fetal ((a): 100x) and adult ((b)-(c): 160x) eyes and seen in GCL, IPL, OPL, and photoreceptor (PR) inner segments. DBC1 was exclusively nuclear in fetal eyes ((d): 100x) with stronger staining in the primitive INL than the ONL. In adult eyes ((e): 400x, (f): 640x), DBC1 was exclusively nuclear in the INL and ONL and both nuclear and cytoplasmic (weak) in the GCL. Of note, GCL and INL nuclei stained stronger than ONL nuclei in all specimens.
