Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain

Figure 2

Effects of IGF-1-containing gelatin hydrogel on neurogenesis in the SVZ. (a) Coronal sections of brains that received an IGF-1 or PBS injection without gelatin hydrogel 7 days before, showing DCX+ new neurons in the SVZ (green) (𝑛=3 animals for each group). (b) Coronal sections of brains that received an injection of microspheres containing IGF-1 or microspheres plus PBS, showing DCX+ new neurons in the SVZ (green) (𝑛=5 animals for each group). (c) Quantification of DCX+ cells in the SVZ. Scale bars: 100 μm (a and b). **𝑃<0.01.

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